摘要
A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 （BABIBOPs） are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of β-aryl and β-alkyl substituted β-keto esters. With the Pd-1.3 （iPr-BABIBOP） catalyst, a series of chiral β-hydroxyl carboxylic esters are formed in excellent enantioselectivities （up to 〉 99% ee） and yields at catalyst loading as low as 0.01 mol%.
A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 （BABIBOPs） are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of β-aryl and β-alkyl substituted β-keto esters. With the Pd-1.3 （iPr-BABIBOP） catalyst, a series of chiral β-hydroxyl carboxylic esters are formed in excellent enantioselectivities （up to 〉 99% ee） and yields at catalyst loading as low as 0.01 mol%.
基金
The work is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences （No. XDB20000000）, CAS （QYZDY-SSW-SLH029）, the National Natural Science Foundation of China （Nos. 21432007, 21572246, 21725205） and K C. Wong Education Foundation.
