摘要
目的 :探讨多种肿瘤标志物对卵巢癌的诊断价值。方法 :应用化学发光法测定卵巢肿瘤、子宫内膜异位症和盆腔炎性包块的CA1 2 5、CA1 99、CA1 5 3、AFP、CEA阳性率。结果 :卵巢癌患者中 ,80 .6 0 %CA1 2 5阳性 ,92 .5 3%联合检测阳性 ,阳性率明显高于良性肿瘤、子宫内膜异位症、盆腔炎性包块患者 (P <0 .0 1 ) ;CA1 2 5与卵巢癌的临床分期及病理类型无关 ,但Ⅰ期卵巢癌患者的血清CA1 2 5值明显低于Ⅱ～Ⅳ期患者 (P <0 .0 1 )。结论 :CA1 2 5对卵巢癌的诊断有一定的价值 ,联合监测能提高卵巢癌的诊断率 ,尤其对早期卵巢癌。
Objective:To study the predictive value of using tumor markers in diagnosis of ovarian cancer. Methods: By using radiochemistry, the positive rates of serum CA125,CA199,CA153,AFP and CEA were measured. Results: There were 54 cases with positive CA125(80.60%) and 62 cases with tumor markers in 67 cases with ovarian cancer, the difference was statistically significant( P <0.05). The positive rates of serum CA125 and tumor markers in ovarian cancer were higher than that in other three groups ( P <0.01). There was significant in stage of ovarian cancer and pathological types by using serum CA125. But the serum CA125 level in stage Ⅱ-Ⅳ was higher than that of stage Ⅰ( P <0.01). Conclusion: It is well worth using in clinics as there is useful value to diagnose ovarian cancer by using serum CA125 and by measuring tumor markers can improve the predictive rate of ovarian cancer, especially for early stages of ovarian cancer.
