摘要
目的:探讨泰能治疗慢性重型肝炎并发自发性细菌性腹膜炎(SBP)的疗效及对肾功能的影响。方法:回顾性分析90例泰能治疗慢性重型肝炎并发SBP案例。结果:首选泰能(先用泰能)治疗20例,病死率为30.0%,其他抗生素应用无效后再用泰能的(后用泰能)70例,病死率为54.3%,两者差异有非常显著性;泰能对单纯并发SBP的重型肝炎疗效达70.4%,出现肝性脑病、肝肾综合征等并发症后疗效低;对肾功能影响不明显。结论:治疗慢性重型肝炎并发SBP时可优先选择泰能。
Objective:To evaluate the effectiveness of Tienam to treat the patients with chronic severe hepatitis complicated with the nosocomial infection of SBP,and its affect on renal function(urea nitrogen;creatinine).Methods: Period analysis was used for 90 patients with chronic severe hepatitis complicated with the nosocomial infection of SBP treated byTienam.Results: Twenty patients were treated withTienam as first-elected candidates of antibiotics,the mortality was 30.0%;being ineffectiveness to treat 70 patients with other antibiotics,then to use Tienam,the mortality was 54.3%,it can be seen that there were great significantly differences.The efficacy of Tienam to treat patients with chronic severe hepatitis complicated with SBP only was as high as 70.4%,however,the patients with chronic severe hepatitis complicated with SBP and hepatic encephalopathy and/or hepatorenal syndrome,the efficacy of Tienam was lower;and no obvious effect was shown on renal function.Conclusions Tienam can be used as a preferential antibiotic to treat the patients with chronic severe hepatitis complicated with SBP.
