戊唑醇原药毒性研究

Study on toxicity of Tebuconazole

目的:研究戊唑醇原药使用的安全性。方法:按GB15670-1995《农药登记毒理学试验方法》进行二阶段毒性测试。结果:戊唑醇原药对雌雄小鼠和雌雄大鼠急性经口LD50(95%可信限)分别为2000(1370~2910),1080(741~1570)mg/kg和2 710(2000~3690),3160(~)mg/kg;雌雄大鼠急性经皮LD50值均】2000 mg/kg;家兔皮肤、眼刺激反应积分均值为0;豚鼠皮肤平均反应值为0,致敏率为0;在受试剂量下,小鼠骨髓细胞微核、睾丸染色体畸变及Ames试验结果均为阴性。结论:该农药属低毒级、无刺激性、弱致敏物,未发现致突变性。

Objective:To study the safety usage of original Tebuconazole.Methods: Two-phase toxicological tests were conducted according to 'Toxicological test methods of pesticides for registration'.Results: The acute oral LD50 and it's 95% IC for female and male mice were 2 000(1 370～2 910) and 1 080(741～1 570) mg/kg respectively,for female and male rats were 2 710(2 000～3 690) and 3 160(～) mg/kg respectively.The values of acute skin LD50 of both female and male rats were all above 2 000 mg/kg;the average values of stimulation for both rabbits' skin and eye score were 0;the average guinea pig skin reaction score was 0,and the sensitization rate was 0.At designed dose experiment,bone marrow polychromatophilic,erythroblasts mutagenesis and ames test were shown as negative results.Conclusion: The original Tebuconazole can be regarded as low level toxicity,without stimulating,weak sensitization and no mutagenicity have found.