γ线不同剂量照射后小鼠胃排空功能的动态变化

THE DYNAMIC CHANGES OF MURINE GASTRIC EMPTYING AFTER DIFFERENT DOSES OF γ-IRRADIATION

本文观察了^(60)Coγ线1.5～12.0Gy照射后30天内小鼠胃排空的动态变化过程.小鼠经1.5及3.0Gy照射,即轻度骨髓型放射病时,胃排空基本无改变或改变较轻微.6.0Gy照射,即中度骨髓型放射病时,早期胃排空明显抑制,一周左右出现短暂加速,然后恢复正常.9.0Gy照射,即重度骨髓型放射病时,早期胃排空抑制更为严重,7～9天虽有加速,但动物死前(13天)胃排空再度抑制.12.0Gy照射,即极重度骨髓型或轻度肠型放射病时,自照后1h始,至动物死亡止,胃排空始终处于高度抑制状态.未见到任何恢复趋势.照射剂量和胃排空损伤程度间有一定的量-效关系.

By photoelectrometric method the changes of gastric emptying within 30 days after 1.5,3,6,9,12Gy γ-irradiation in mice were observed.Following 1.5 and 3Gy irradiation (mild hemopoietic type of radiation sickness) there were no changes or only slight delay in gastric emptying,but after 6 and 9Gy irradiation (moderate and severe acute hemopoietic type of radiation sickness) the gastric emptying delayed more conspicuously and continued for about one week.Following 12Gy irradiation (extremely severe hemopoietic or mild gastro-intestinal types of radiation sickness) the gastric emptying was delayed very drastically and did not recover until death occurred.Based on these data several important principles had been put forward for the clinical diagnosis and therapy.