游泳对大鼠胃肠动力及血浆胃动素的影响

Effect of swimming on the gastrointestinal motility and plasma motilin in rats

目的 :观察游泳对大鼠胃肠动力的影响。方法 :大鼠植入胃肠测压管 ,用低顺应性毛细管水灌注系统记录大鼠游泳前后胃和十二指肠压力变化 ,并抽静脉血测定血浆胃动素浓度。 结果 :大鼠游泳 30 min后胃和十二指肠的收缩振幅、频率和动力指数明显比游泳前增加 (P<0 .0 5和 P<0 .0 1)。游泳后大鼠血浆胃动素浓度 [(15 9.0 2± 43.39) ng/L]显著高于游泳前[(94.5 2± 2 0 .2 7) ng/L](P<0 .0 1)。 结论 :上述结果提示适度运动锻炼能增强胃肠运动功能 ,升高的血浆胃动素可能参与加强运动后胃和十二指肠的收缩。

Objictive To observe the effect of swimming on gastrointestinal motility in rats. Methods Manometric catheter was chronically implanted into rat's gut. The Pressures of antrum and duodenum were recorded using low compliance capillary water perfusion system, and venous blood samples were taken for measuring plasma motilin. Results After swimming of 30 min in duration, The amplitude、frequency and motility index of contractions of antrum and duodenum significantly increased as compared with prior to swimming ( P <0.05 and P <0.01). Plasma motilin levels were higher after swimming (159.02±43.39 ng/L) than before exercise (94.52±20.27 ng/L) ( P <0.01). Conclusions The results suggest that moderate exercise can enhance gastrointestinal motility, and elevated plasma motilin concentration may play a role in the increased contraction of antrum and duodenum after exercise.