摘要
稀土上转换发光纳米颗粒(UCNPs)可将近红外光转化为紫外可见光,能有效解决光动力抗菌疗法(PACT)中组织穿透深度小、治疗效率低的问题。综述了基于稀土上转换发光纳米平台的光动力抗菌疗法的研究进展,并对新型联合抗菌平台的开发及其在临床上的应用进行了展望。
Rare earth upconversion nanoparticles（UCNPs）can transform near-infrared light into ultraviolet-visible light,which can effectively solve the problems such as a low tissue penetration depth and a low treatment efficiency of photodynamic antimicrobial chemotherapy（PACT）.The research progress on the photodynamic antimicrobial chemotherapy based on rare earth upconversion nanoplatforms is reviewed.The development of novel coantibacterial platform and its clinical applications are prospected.
作者
赵一铭
刘成程
王晶
胡敏
Zhao Yiming1, Liu Chengcheng2, Wang Jing3, Hu Min1(1Department of Chemistry, School of Science, Xi＇an Jiaotong University, Xi＇an, Shannxi 710049, China; 2 Department of Pathogenic Microbiology ＆ Immunology, School of Basic Medical Sciences, Xi＇an Jiaotong University Health Science Center, Xi＇an, Shannxi 710061, China; Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi＇an Jiaotong University, Xi＇an, Shannxi 710049, Chin)
出处
《中国激光》
EI
CAS
CSCD
北大核心
2018年第2期171-179,共9页
Chinese Journal of Lasers
基金
国家自然科学基金(81401710
61335012)
中央高校基本科研业务费专项资金
关键词
医用光学
光动力抗菌疗法
稀土上转换纳米颗粒
协同治疗
多重耐药菌
medical optics
photodynamic antimicrobial chemotherapy
rare earth upconversion nanoparticles
combination therapy
multidrug-resistant bacteria
