动脉粥样硬化患者载脂蛋白C3高表达

Study on the level of apolipoprotein C3 in peripheral blood of patients with atherosclerosis

目的检测载脂蛋白C3(APOC3)在动脉粥样硬化患者血清中的表达变化。方法全自动生化分析仪检测并分组比较20例冠状动脉无狭窄的心脏病患者和195例冠状动脉有狭窄的心脏病患者外周血总APOC3及亚组APOC3(HDL-APOC3、TRL-APOC3)水平。结果冠状动脉狭窄的心脏病患者血清APOC3水平高于无狭窄的心脏病患者(P<0.05),冠心病(CHD)患者(至少1支冠状动脉直径狭窄≥50%)血清APOC3水平高于非CHD患者(P<0.05),APOC3各亚组分(HDL-APOC3、TRL-APOC3)在各组之间差异无显著意义,不同程度狭窄组患者之间APOC3水平无显著性差异(P>0.05)。结论血清总APOC3浓度在冠脉狭窄患者中高表达,但与狭窄的程度无显著关系。APOC3可以作为CHD的潜在独立风险因子。

Objective To investigate the role of apolipoprotein C3（APOC3）in the development of atherosclerosis.Methods Peripheral blood APOC3 was measured by fully-automatic biochemical analyzer and compared respectively in20 heart disease patients with coronary artery without stenosis and 195 heart disease patients with narrow coronary artery.Results The level of serum APOC3 in heart disease patients with coronary artery stenosis was higher than the heart disease patients with coronary artery without stenosis（P〈0.05）,the level of serum APOC3 in Coronary artery heart disease（CHD）patients was higher than the non-CHD patients（P〈0.05）.There was no significant difference between the levels of APOC3 in patients with stenosis（P〈0.05）.Conclusion serum total APOC3 was increased in patients with coronary artery stenosis,it has no significant differences with the degree of stenosis.APOC3 may be used as an independent risk factor for CHD.