高血压合并NAFLD的Scr、BMI、HDL-C检测及其临床意义

Clinical Significance of Scr,BMIand HDL-C inHypertension complicated with NAFLD

目的探讨高血压合并非酒精性脂肪肝(NAFLD)患者的危险因素,为其预防及治疗提供方向。方法选取2016年1月至2017年8月就诊于吉林大学中日联谊医院的原发性高血压患者,根据超声或CT/MRI影像的结果分为单纯高血压组(54例)与高血压合并NAFLD组(53例),检测体质量指数(BMI)、外周血红细胞计数(RBC)、血红蛋白(HGB)、红细胞平均体积(MCV)、红细胞平均血红蛋白浓度(MCHC)、平均红细胞体积分布宽度(RDW)、空腹血糖(FBG)、血肌酐(Scr)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)、脂蛋白a[LP(a)]、天门冬氨酸氨基转移酶(AST)、谷丙转氨酶(ALT)、谷氨酰转肽酶(GGT),同时统计患者高血压分级、是否合并糖尿病,比较两组统计指标差异性,并通过logistics回归分析分析高血压合并NAFLD的独立危险因素。结果合并NAFLD组与单纯高血压组相比,BMI、MCV、FBG、Scr、HDL-C、ALT均显著升高。多因素logistics回归分析提示Scr、BMI、HDL-C为高血压合并非酒精性脂肪肝的独立危险因素。结论 Scr、BMI、HDL-C为高血压合并非酒精性脂肪肝的独立危险因素,在高血压合并NAFLD的发病中起重要作用。

Objective To explore the risk factors in patients ofHypertension complicated withnonalcoholic fatty liver disease（NAFLD）,provide direction for its prevention and treatment.Methods Randomly selected 54 patients with essential hypertension,and 53 with Combination of Hypertension and NAFLD from patientsrefered to China-Japan Union Hospital.All the patients hadultrasound/CT/MRI.Detected the body mass index（BMI）,peripheral blood red blood cell count（RBC）,hemoglobin（HGB）,mean corpuscular volume（MCV）,mean corpuscular hemoglobin concentration（MCHC）,average red blood cell volume distribution width（RDW）,fasting blood glucose（FBG）,serum creatinine（Scr）,triglycerides（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein-A1（Apo-A1）,apolipoprotein-B（Apo-B）and lipoprotein（a）（LP（a））,aspartate aminotransferase（AST）,alanine aminotransferase（ALT）,gamma glutamyl transpeptidase（GGT）,hypertension classification and diabetes mellitus.Compared statistics index differences of two groups,and analysised independent risk factors through the logistics regression analysis.Results Comparing with the pure hypertension group,BMI,MCV,FBG,Scr,HDL-C and ALT were significantly increased in the combination of NAFLD group.Multiple factors logistics regression analysis suggestedthat Scr,BMIand HDL-Cwere independent risk factors for the development of hypertension combined with NAFLD.Conclusion As independent risk factors for hypertension with nonalcoholic fatty liver disease,Scr,BMI,and HDL-C play important roles in the pathogenesis of hypertension with NAFLD.