NRF2启动子区-617G/T多态性与胶质瘤易感性的关联

Association between-617G/T polymorphism in the promoter of NRF2 and risk of glioma

目的探讨NRF2启动子区rs6721961多态性与胶质瘤的相关性。方法收集156例胶质瘤和185例性别和年龄匹配的对照样本,采用Taqman基因分型技术对NRF2rs6721961进行分型。结果 rs6721961GG、GT和TT基因型在对照组中的频率分别为48.6%、45.4%和5.9%,在胶质瘤组中分别为39.7%、46.8%和13.5%。经卡方检验,携带TT基因型者患胶质瘤的风险增加了2.77倍(χ2=6.59,P=0.01)。G和T等位基因在对照组中频率分别为71.4%和28.6%,在胶质瘤组中的频率分别为63.1%和36.9%,经卡方检验,携带T等位基因者患胶质瘤的风险增加了1.45倍(χ2=5.21,P=0.02)。结论 NRF2启动子区rs6721961多态性可能是胶质瘤的易感因素。

Objective To investigate the association between rs6721961 polymorphism in the promoter of NRF2 and risk of glioma.Methods One hundred and fifty-six glioma patients and 185 gender and age-matched controls were enrolled in this study.The rs6721961 polymorphism was genotyped using Taqman technique.Results The frequencies of the rs6721961GG,GT and TT were 48.6,45.4and 5.9%in controls and 39.7,46.8 and 13.5% in patients with glioma.After chi-square test,we found that the TT genotype had a 2.77-fold increased risk of glioma（χ~2=6.59,P=0.01）.The frequencies of the rs6721961G and T were 71.4and 28.6%in controls and 63.1 and 36.9% in patients with glioma.Chi-square analysis showed that the T allele had a 1.45-fold increased risk of glioma（χ~2=5.21,P=0.02）.Conclusion The rs6721961polymorphism in the promoter of NRF2may be a susceptibility factor for glioma.