摘要
目的研究伏立康唑致精神异常发生率与血浆谷浓度的关系。方法回顾性分析中南大学湘雅医院2016年5月~2017年5月监测的151名患者伏立康唑血浆谷浓度与精神异常的发生情况。结果 151例患者中,多梦的总体发生率为21.85%,Logistic二项回归分析结果表明,多梦与血浆谷浓度成正相关(P=0.02)。幻觉的总体发生率为15.23%,Logistic二项回归分析结果表明,幻觉与血浆谷浓度成显著正相关(P=0.002)。结论伏立康唑致精神异常发生率与血浆谷浓度有良好相关性。
OBJECTIVE To explore the correlation between voriconazole＇s trough concentration and mental abnormity. METH- ODS Retrospectively analyze voriconazole＇s trough concentration and the occurrence of mental abnormity in 151 patients from May 2016 to May 2017 in Xiangya Hospital. RESULTS In 151 patients, Insomnia rate is 21.85%, binary logistic regression analysis showd that the insomnia rate is positively related to voriconazole＇s trough concentration （P = 0. 02）. Illusion rate is 15.23%, binary lo- gistic regression analysis showd that the illusion rate is positively related to voriconazole＇ s trough concentration （ P = 0. 002 ） . CONCLUSION There is a significant correlation between voriconazole＇s mental abnormity and trough concentration.
作者
戴婷婷
胡林
李逃明
唐勇军
DAI Ting-ting;HU Lina;LI Tao-minga;TANG Yong-junb(a. Department of Pharmac;b. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, Chin)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2018年第5期375-378,共4页
Chinese Pharmaceutical Journal
关键词
伏立康唑
精神异常
药物不良反应
谷浓度
voriconazole
mental abnormity
adverse drug reaction
trough concentration
