DYRK1B蛋白在宫颈癌组织中的表达及意义

Expression and significance of DYRK1B protein in cervical carcinoma B

目的探讨双特异性酪氨酸磷酸化调节激酶1B(DYRK1B)蛋白在宫颈癌组织中的表达情况及其临床意义。方法选取84例宫颈癌病理组织标本(宫颈癌组)、40例宫颈上皮内瘤变(CIN)组织标本(CIN组)、40例正常宫颈组织标本(对照组),采用免疫组织化学染色方法检测3组标本中DYRK1B蛋白的表达情况,并探讨DYRK1B蛋白表达与宫颈癌病理特征的关系。结果宫颈癌组中DYRK1B蛋白的阳性表达率为72.62%,高于CIN组中的22.50%和对照组的12.50%(P﹤0.05);CIN组和对照组中的DYRK1B蛋白的阳性表达率比较,差异无统计学意义(P﹥0.05);不同临床分期、组织浸润深度、分化程度、淋巴结转移情况的宫颈癌组织中DYRK1B蛋白的阳性表达率比较,差异均有统计学意义(P﹤0.05);而不同年龄、病理学类型的宫颈癌组织中DYRK1B蛋白的阳性表达率比较,差异均无统计学意义(P﹥0.05)。结论 DYRK1B蛋白在宫颈癌组织中表达上调,可能与宫颈癌的发生发展有关。

Objective To investigate the expression of Dual-specificity tyrosine phosphorylation regulated kinase 1 B（DYRK1 B） in cervical carcinoma tissues and the clinical significance.Method 84 cases of specimens of cervical cancer tissues（cervical cancer group）,40 specimens of cervical intraepithelial neoplasia tissues（CIN group） and 40 specimens of normal cervical tissues（control group） were collected,in which the expression of DYRK1B protein was detected by immunohistochemical staining,the relationship between the expression of DYRK1B protein and the clinicopathological features of cervical cancer was discussed.Result The positive expression rate of DYRK1B protein in cervical cancer tissues was 72.62%,which was significantly higher than that in CIN tissues（22.50%） and in control group（12.50%）（P〈0.05）; there was no significant difference in DYRK1B protein expression between CIN group and control group（P〈0.05）;clinical stages,depth of invasion,differentiation,lymph node metastasis were associated with the positive expression rate of DYRK1B protein（P〈0.05）; while age and pathological type were not（P〈0.05）.Conclusion DYRK1B protein expression is upregulated in cervical cancer,which may be involved in the occurrence and development of cervical cancer.