Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌中的临床表达意义

Clinical Significance of Survivin and Bcl-2 Expression in Squamous Cell Carcinoma of Nasal Cavity and Paranasal

目的探讨Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌(SNSCC)中的临床表达意义。方法选取SNSCC患者35例、SNIP患者35例以及下鼻甲黏膜患者35例,检测3组患者的Survivin及Bcl-2表达。结果在不同分化SNSCC患者的组织当中,肿瘤分化越高,患者的Survivin表达越低,但差异无统计学意义(P>0.05);在不同分化SNSCC患者的组织当中,肿瘤分化越高,患者的Bcl-2表达越低,差异有统计学意义(P<0.05)。SNSCC患者以及SNIP患者的Survivin表达率显著高于下鼻甲黏膜组患者(P<0.05),但SNSCC与SNIP患者之间对比无明显差异(P>0.05);SNSCC患者的Bcl-2表达率显著高于SNIP患者以及下鼻甲黏膜组患者(P<0.05)。结论 Survivin及Bcl-2表达与SNSCC的发生发展有重要的联系,可以作为基因治疗的靶点。

Objective To investigate the clinical significance of Survivin and Bcl-2 in nasal cavity and paranasal squa- mous cell carcinoma （SNSCC）. Methods 35 patients with SNSCC,35 patients with SNIP and 35 patients with inferior turbinate mucosa were enrolled. Survivin and Bcl-2 were detected in the 3 groups of patients. Results The expression of Survivin was lower in patients with higher stage of SNSCC, but the difference was not statistically significant （ P 〉 0.05 ）. The higher the grade of SNSCC patients, the lower the expression of Bcl-2, the difference was statistically significant （P 〈 0.05） ; The expression of Sur- vivin in SNSCC patients and SNIP patients were significantly higher than that of patients with inferior turbinate mucosa （P 〈 0.05）, but there was no significant difference between SNSCC and SNIP patients （P 〉 0.05）. The expression of Bcl-2 in SNSCC patients was significantly higher than those of patients with SNIP and inferior turbinate mucosa （ P 〈 0.05 ）. Conclusion The ex- pression of Survivin and Bcl-2 are closely related to the development and progression of SNSCC. It can be used as a target for gene therapy.