双氯芬酸与塞来昔布联合阿片类药物对转移性骨癌痛的临床效果

The Clinical Effect of Diclofenac and Celecoxib Combined with Opioid on Metastatic Bone Cancer Pain

目的综合分析双氯芬酸与塞来昔布联合阿片类药物治疗转移性骨癌痛的临床效果。方法选取78例糖尿病合并ACVD患者作为研究对象,按照不同的治疗方法分为实验组与对照组,每组均为39例。对照组应用阿片类药物(环磷酰胺片)治疗,实验组应用双氯芬酸与塞来昔布联合阿片类药物(环磷酰胺片)治疗。结果治疗前两组患者的视觉疼痛模拟评分比较无统计学意义(P>0.05);治疗后第14天、第21天、第28天实验组视觉疼痛模拟评分显著低于对照组(P<0.05);(2)治疗后第14天、第21天、第28天实验组疼痛缓解率远远高于对照组(P<0.05);(3)治疗前一天,两组患者的癌痛发作次数比较无统计学意义(P>0.05);治疗后第14天、第21天、第28天实验组癌痛发作次数显著少于对照组(P<0.05);(4)治疗后第14天、第21天、第28天实验组吗啡用量显著少于对照组P<0.05);(5)实验组嗜睡、便秘等不良反应发生率显著低于对照组(P<0.05)。结论双氯芬酸与塞来昔布联合阿片类药物控制转移性骨癌痛的临床效果显著。

Objective To analyze the clinical effect of diclofenac combined with celecoxib combined with opioid on me- tastatic bone cancer pain. Methods 78 patients with diabetes mellitus and ACVD treated in our hospital were selected and divid- ed into experimental group and control group according to different treatment methods, example. The control group was treated with opioid （Cyelophosphamide Tablets）. The treatment group was treated with diclofenac and celecoxib combined with opioid （Cyclo- phosphamide Tablets）. SPSS20.0 statistical software was used to analyze the visual analogue scale, opioid dose, adverse reaction rate, pain relief rate and the number of cancer pain episodes in the two groups. Results ① There was no significant difference in visual analogue scores between the 2 groups before treatment （ P 〉 0.05 ）. On the 14th day, the 21st day and the 28th day after treatment, the visual analogue score of the experimental group was significantly lower than that of the control group （ P 〈 0.05 ）. ② The pain relief rate of the experimental group was significantly higher than that of the control group on the 14th day, the 21st day and the 28th day after treatment （ P 〈 0.05 ） ; ③The day before the treatment, （ P 〈 0.05 ） ; The number of cancer pain in ex- perimental group on the 14th day,the 21st day and the 28th day after treatment was significantly less than that of the control group （P 〈 00. 05 ） ;④the 14th and 21st day after treatment （P 〈 0.05 ） ;⑤The incidence of side effects such as drowsiness and consti- pation was significantly lower in the experimental group than that of the control group （ P 〈 0.05 ）. Conclusion Diclofenac and celecoxib combined with opioid have a significant clinical effect in controlling metastatic bone cancer pain.