寒区军人功能性消化不良与幽门螺杆菌感染关系研究

Correlation between the helicobacter pylori infection and functional dyspepsia in soldiers under severe cold condition

目的探讨寒区军人功能性消化不良(FD)与幽门螺杆菌(Hp)感染的关系。方法采用整群抽样的方法,应用功能性胃肠病罗马Ⅳ诊断标准中的症状自评量表,对北纬45°~50°驻军的450名官兵进行问卷调查。对患有FD的官兵进一步行14C尿素呼气试验,检查是否感染Hp,并与未患FD官兵(健康组)的Hp感染情况进行比较分析。结果本研究共收回426份有效问卷,FD发病患者66例,发生率15.5%(66/426)。其中,餐后不适综合征发生率为9.6%(41/426),上腹痛综合征发生率为5.9%(25/426)。依据不同并发症进一步分析发现,餐后饱胀发生率为6.1%(26/426);上腹烧灼感发生率为1.9%(8/426);上腹痛发生率为3.5%(15/426);早饱发生率为2.8%(13/426);恶心发生率为1.6%(7/426);呕吐发生率为0.9%(4/426);厌食发生率为2.6%(11/426);嗳气发生率为3.8%(16/426);其中,混合多种症状19例,发生率为4.5%(19/426)。FD组Hp感染率为28.8%(19/66),显著高于健康组的13.6%(9/66),组间比较,差异有统计学意义(P<0.05)。结论寒区官兵FD发生率较高,以餐后不适综合征较常见,餐后饱胀和混合症状为主要表现;患病官兵Hp感染率较高,应重视Hp感染在寒区官兵FD治疗中的影响。

Objective To investigate the correlation between the helicbacter piloril （Hp） infection in the soldiers under severe cold condition. Methods According to cluster sampling,450 soldiers stationed in latitude 45°-50° garrison were recruited. The standard questionnaire of Rome IV was used to perform investigation. The infection of Hp （ FD group） was inspected through 14 C urea breath test, and the situation of Hp infection was compared and analyzed with those without FD （ healthy group）. Results A total of 426 valid questionnaires were returned. There were 66 cases of FD, the incidence of FD was 15.5% （66/426）, including postprandial distress syndrome was 9. 6% （41/426） and epigastric pain syndrome was 5.9% （25/426）. According to the further analysis of different com- plications, the rate of fullness after meal was 6. 1% （26/426） ; the incidence of epigastric burning was 1.9% （8/426） ; the incidence of epigastric pain was 3.5% （15/426） ; the incidence of early saturation was 2. 8% （13/426） ; the incidence of nausea was 1.6% （7/426） ;the incidence of vomiting was 0. 9 % （4/426） ;the incidence of anorexia was 2. 6% （11/426） ;the incidence of belching was 3.8 % （16/426） ;among them, 19 cases were mixture of different syndromes and the incidence was 4. 5 % （19/426）. The infection of Hp was 28.8% （19/66） in FD group,which was significantly higher than 13.6% （9/66） in the healthy group（P 〈0.05）. Conclu- sion The incidence of FD is a common disease among the soldiers under severe cold condition. Postprandial fullness and mixture of different symptoms are the main clinical manifestations. The infection of Hp in the FD group is higher. Therefore, attention should be paid to the role of Hp infection in the treatment of FD among the soldiers under severe cold condition.