摘要
目的探讨类固醇生长因子1(SF1)和细胞角蛋白8(CK8)在垂体腺瘤分类中的指导作用。方法收集垂体腺瘤49例,检测SF1和CK8在垂体腺瘤中的表达,分析二者在不同类型垂体腺瘤中的表达特点。结果 SF1在促性腺激素细胞腺瘤中的阳性表达率(90%,18/20)明显高于其他类型垂体腺瘤(0);CK8在SF1阳性的垂体腺瘤中的高表达率(21%,5/24)明显低于SF1阴性的垂体腺瘤(92%,23/25)。结论 SF1对促性腺激素细胞腺瘤有极高的诊断价值;CK8阴性或低表达是促性激素细胞腺瘤的分子特征之一,可以辅助用于垂体腺瘤的分类。
Objective To investigate the role of SF1 and CK8 in the classification of pituitary adenomas. Methods The ex- pressions of SF1 and CK8 in 49 pituitary adenomas were detected by immunohistochemistry. The difference of the expression （SF1 and CK8） in multiple pituitary adenoma were analyzed. Results The rate of SF1 positive staining in gonadotroph adenoma （90%, 18/20） was significantly higher than that in other pituitary adenoma types （0% ,0/11） （P〈0. 01） ;the rate of CK8 high expres- sion in SF1 immunopositive pituitary adenoma （5/24,21 %） was significantly lower than that in SF1 immunonegative pituitary ad- enoma （23/25,920/00）. Conclusion SF-1 is a key molecular event and play a important role in the diagonosis of gonadotroph adeno- ma. CK8 immunonegative or low expression is one of the molecular characteristics of the gonadotroph adenoma, and it can be used for the classification of pituitary adenoma.
作者
吴会芳
王俊宽
常佳
顾斌
冯怡锟
杨婉菁
张岩
胡桂明
陈琛
任景丽
WU Huifang1） ,WANG Junkuan2） , CHANG J ia1） , GU Bin1） , FENG Yikun1） , YANG Wanjing1） , ZHANG Yan1）, HU Guim- ing1） ,CHEN Chen1） ,REN Jingli1）＊(1 ）Department of Pathology, the Second Affiliated Hospital of Zhengzhou University ,Zhengzhou 450014 ,China;2）Department of Neurosurgery , the First Affiliated Hospital of Zhengzhou University ,Zhenzhou 450052, China)
出处
《中国实用神经疾病杂志》
2018年第4期353-356,共4页
Chinese Journal of Practical Nervous Diseases
基金
河南省自然科学基金(162300410307)
