维生素D_2对高龄女性血清25-羟基维生素D的影响

Influence of intramuscular injection of vitamin D_2 on serum 25-hydroxyvitamin D in aged women

目的了解肌内注射维生素D_2对高龄女性血清25-羟基维生素D的影响。方法将40例高龄女性随机分为试验组20例和对照组20例。试验组在坚持晒太阳的基础上,连续3个月肌内注射维生素D_2个60万U;对照组仅坚持晒太阳。所有高龄女性在治疗前和治疗后1~8个月,每月测1次血清25-羟基维生素D和血钙,比较2组高龄女性的血清25-羟基维生素D和血钙的差异。结果试验组高龄女性在治疗后第3个月血清25-羟基维生素D水平为(19.76±3.28)ng·mL^(-1),对照组为(16.37±3.01)ng·mL^(-1),差异有统计学意义(P<0.01),但在其他时间2组差异均无统计学意义(均P>0.05)。2组高龄女性患者治疗期间血钙之间的差异均无统计学意义(均P>0.05)。结论连续肌内注射3次维生素D_2,可提高高龄女性血清25-羟基维生素D水平,且对血钙水平无影响。

Objective To evaluate the influence of intramuscular injec- tion of vitamin D2 on serum 25 - hydroxyvitamin D in aged women. Methods A total of 40 aged women were randomly divided into treatment group and control group, each group 20 patients. Patients in treatment group were given vitamin D2 injection 6. 0 ×10^5 U every month, intramuscular injection, for 3 months. Control group was given sunshine treatment. The levels of serum 25 - hydroxyvitamin D and calcium were evaluated and compared before treatment and after 8 months treatment. Results After 3 months treatment, serum 25 - hydroxyvitamin D in treatment group and control group were （ 19.76 ± 3.28 ）, （16.37 ± 3.01 ） ng·mL-1, with significant difference （P 〈 0. 01 ）, and the levels of serum 25 - hydroxyvitamin D in other times had no significant difference （ all P 〉 0.05 ）. There was no significant difference in serum calcium between treatment and control group during 9 months （ all P 〉 0. 05 ）. Conclusion Vitamin D2 injection could be used to increase serum 25 -hydroxyvitamin D level, and it had no effect on serum calcium.