健康指导对阿仑膦酸钠治疗骨质疏松症患者服药依从性和有效性的影响

The effect of health guidance on medication compliance and effectiveness of patients with osteoporosis treated by alendronate sodium

目的探讨健康指导对阿仑膦酸钠治疗骨质疏松症（OP）患者服药依从性和有效性的影响。方法选取本院自2015年8月至2016年8月间收治的OP患者130例作为研究对象，随机将其分成两组，对照组65例患者采用小剂量阿仑膦酸钠治疗，观察组65例患者在对照组基础上进行健康指导，连续治疗12个月对比两组患者治疗后不同时段的服药依从性、不良反应情况以及患者对OP认知功能的差异。其中，服药依从性包含服药持续性和顺应性，分别以服药的持续时间、药物持有率表示。结果治疗3个月时，两组患者的顺应性率和药物持有率差异无统计学意义（P〉0．05）；治疗6个月、12个月时，观察组服药依从性均高于对照组，差异有统计学意义（P〈0．05）。治疗前两组患者OP认知量表评分差异无统计学意义（P〉0．05），治疗后观察组评分显著优于对照组，差异有统计学意义（P〈0．05）。治疗期间观察组不良反应发生率为4．62％，对照组为6．18％，两组的不良反应发生率差异无统计学意义（P〉0．05）。结论健康教育能够提升阿仑膦酸钠治疗患者服药依从性和治疗的安全性，加强患者对疾病知识的了解，因此值得推广。

Objective To explore the effect of health guidance on medication compliance and effectiveness of patients with osteoporosis （OP） treated by alendronate sodium. Methods 130 cases of patients with OP treated in our hospital from August 2015 to August 2016 were selected as the object of study, and were randomly divided into two groups. 65 cases in the control group were treated with small dose of alendronate sodium, 65 cases in the observation group were given health guidance on the basis of the control group. After continuous treatment of 12 months, compared the medication compliance at different time points, adverse reactions, cognitive function on OP of the two groups. Medication compliance included medication continuity and compliance, which were represented by the duration of medication and medication possession ratio （MPR） respectively. Results There were no statistically significant differences in MPR and compliance between the two groups at 3 months after treatment （P〉0.05）; MPR and compliance in the observation group were higher than those in the control group at 6 and 12 months after treatment, with statistically significant differences （P〈0.05）. There were no statistically significant differences in OP cognitive scale scores between the two groups before treatment （/〉〉0.05）; the scores in the observation group were higher than those in the control group after treatment （P〈0.05）. The incidence of adverse reactions during the treatment was 4.62% in the observation group and 6.18% in the control group, without statistically significant difference between the two groups （P〉0.05）. Conclusion Health education can improve medication compliance and the safety of treatment of patients treated by alendronate sodium, strengthen the understanding on disease related knowledge of the patients, is worth promoting.