血管紧张素转化酶基因多态性与结直肠癌易感性关系的Meta分析

The relationship between angiotensin-converting enzyme polymorphism and the susceptibility of colorectal cancer: a Meta-analysis

目的探讨血管紧张素转化酶(angiotensin-converting enzyme,ACE)基因多态性与结直肠癌(colorectal cancer,CRC)易感性之间的关系。方法检索截至2017年4月各数据库发表的关于评价ACE基因多态性与CRC关系的研究,进行数据分析。结果有7篇文献符合纳入标准,共7 813例患者纳入研究,其中病例组908例,对照组6 905例。ACE基因的3种基因型包括:缺失纯合子型(DD型)、插入纯合子型(II型)、缺失与插入纯合子型(ID),隐性基因模型比值比(OR)为1.10(95%CI:0.91~1.33),差异无统计学意义(P=0.34)。显性基因模型OR为0.25(95%CI:0.08~0.81),差异有统计学意义(P=0.02)。结论在显性基因模型下,ACE基因对CRC的发生有抑制作用。

Objective To investigate the relationship between angiotensin-converting enzyme（ACE） polymorphisms and the susceptibility of colorectal cancer（ CRC）. Methods The literatures published on databases which studied the relationship between ACE polymorphisms and the susceptibility of CRC until Apr. 2017 were searched. Results A total of 7 references met the inclusion criteria. A total of 7 813 cases were included in the study,including 908 patients with CRC and 6 905 healthy controls. The three genotypes of ACE gene included： deletion of zygote（ DD type）,insertion of zygote（II type）,and the deletion and insertion of homozygous type（ID type）,recessive model odds tatio（OR） was 1. 10（95% CI： 0. 91-1. 33,P =0. 34）. Dominant model OR was 0. 25（95% CI： 0. 08-0. 81,P = 0. 02）. Conclusion Under the dominant genetic model,the ACE probably has some effect to restrain the happen of CRC in people.