饮料饮用量与溃疡性结肠炎发病风险相关性的Meta分析

Beverage consumption and risk of ulcerative colitis: a Meta-analysis

目的评价溃疡性结肠炎(ulcerative colitis,UC)发病风险与饮料饮用量之间的关系。方法在Pub Med、Embase和Cochrane Library数据库上进行搜索获得所有相关的研究。结果共纳入13个研究,包括3 246例UC患者和5 494例对照,综合分析显示,酒精性饮料的饮用量与UC发病风险无关(RR=0.95,95%CI:0.72~1.26,I^2=65.7%,n=6),但在亚洲人群亚组内呈显著正相关(RR=1.33,95%CI:1.05~1.69,I^2=45.4%,n=3);咖啡的饮用量与UC的发病风险可能存在负相关(RR=0.58,95%CI:0.33~1.05,I^2=87.5%,n=6);软饮料的饮用量与UC的发病率呈正相关(RR=1.66,95%CI:1.27~2.19,I^2=12.9%,n=5),尤其在高加索人群中(RR=1.84,95%CI:1.32~2.57);茶的饮用量与UC的发病风险也呈负相关(RR=0.70,95%CI:0.58~0.84,I^2=0,n=2)(两项研究对象均为亚洲人群)。结论此次Meta分析提示,大量饮用软饮料可增加UC的发病风险,而多喝茶可降低此类风险。

Objective To evaluate the association between beverage consumption and the risk of ulcerative colitis（UC）. Methods A comprehensive search was performed in Pub Med,Embase and Cochrane Library databases to identify all relevant studies. Results A total of 13 studies involving 3 246 cases and 5 494 controls were included in this Meta-analysis. In pooled analysis of the highest vs the lowest categories,alcohol consumption was not associated with the risk of UC（ RR = 0. 95,95% CI： 0. 72-1. 26,I2= 65. 7%,n = 6）,but it was significant in Asian cohorts（ OR =1. 33,95% CI： 1. 05-1. 69,I2= 45. 4%,n = 3）. Coffee consumption had a possible inverse association with the risk of UC（ RR = 0. 58,95% CI： 0. 33-1. 05,I2= 87. 5%,n = 6）. The consumption of soft drinks was associated with the risk of UC（ RR = 1. 66,95% CI： 1. 27-2. 19,I2= 12. 9%,n = 5）,especially in Caucasian cohorts（ RR = 1. 84,95% CI： 1. 32-2. 57）. Tea consumption had a reverse association with the risk of UC（ RR = 0. 70,95% CI： 0. 58-0. 84,I2= 0,n = 2）（ Both of the included studies were Asian-cohorts-based）. Conclusion This Meta-analysis indicated that increased consumption of soft drinks might be associated with the risk of UC,while increased consumption of tea might reduces the risk.