斜视儿童生存质量量表在斜视儿童术前生存质量评估中的临界值研究

Study on critical value of child intermittent exotropia questionnaire in preoperative quality of life assessment for strabismus children

目的确定斜视儿童生存质量量表(Child-IXTQ)在斜视儿童术前生存质量评估中的适宜临界值。方法对106例斜视儿童术前进行Child-IXTQ和儿童生存质量量表(PedsQL4.0)的测评,并以PedsQL4.0作为测评ChildIXTQ的效标,通过对Child-IXTQ各分值对应的灵敏度,特异度计算绘制受试者工作特征曲线(ROC曲线)得出Child-IXTQ在斜视儿童术前生存质量状况评估中的应用,从而确定最佳临界值。结果 Child-IXTQ的得分与儿童生存质量量表PedsQL4.0表得分呈正相关(r=0.609,P<0.01);当Child-IXTQ临界值为67分时,受试者工作特征(ROC)曲线在左上方离标准参照线最远,此时灵敏度、特异度分别为0.929和0.893,ROC曲线下面积为0.902(P<0.01),标准误差为0.052。结论 Child-IXTQ在斜视儿童术前生存质量评估中的最佳临界值是67分,是斜视儿童术前生存质量测评的有效工具。

Objective To identify the optimal critical value of the child intermittent exotropia questionnaire （Child-IXTQ） in preoperative quality of life assessment for strabismus children. Methods A prospective cohort of 106 strabismus children were recruited to complete the Child-IXTQ and PedsQL4.0 questionnaire, and the PedsQL4.0 was used as the criterion for evaluating Child-IXTQ. Through the sensitivity and specificity calculation of each score corresponding to Child-IXTQ, we draw the receiver working characteristic curve （ROC curve） to get the application of Child-IXTQ in e- valuating the quality of life of strabismus children before operation so as to determine the best critical value. Results The score of Child - IXTQ was positively correlated with the score of PedsQL7.0 （r = 0.609, P 〈 0.01）. The optimal critical value for Child-IXTQ was 67 scores, the subject＇s operating characteristic （ROC） curves is the farthest from the stan- dard reference line in the upper left. The sensitivity and specificity were 0.929 and 0.893 respectively, the areas under the curve was 0.902 （P 〈 0.01）, and the standard error was 0.052. Conclusion The optimal critical value of Child-IXTQ for the strabismus children is 67 scores, and it is an effective tool for preoperative assessment for quality of life of stra- bismus children.