《金匮要略》方治疗肝硬变循证医学研究

The Evidence-Based Medical Research into Cirrhosis Treated with Formulas in Essentials from the Golden Cabinet

目的:通过循证医学方法探寻《金匮要略》方治疗肝硬变的方剂运用规律。方法:检索文献获取《金匮要略》方治疗肝硬变的优势方剂谱,并使用已拟定的文献评价标准对临床研究文献及个案报道文献进行评价,进而获得肝硬变在现代临床环境下的中医证型。结果:明确《金匮要略》方治疗肝硬变的临床研究文献有106篇,个案经验文献有113篇,常用方剂为大黄虫丸、鳖甲煎丸、防己椒目葶苈大黄丸及下瘀血汤。结论:大黄虫丸、鳖甲煎丸、防己椒目葶苈大黄丸和下瘀血汤的证型很可能是肝硬变在现代临床环境下的主要证候表现。

Objective： To explore the application law of formulas in Essentials from the Golden Cabinet by the method of evidencebased medicine. Methods： The literatures on dominant formula spectrum treating cirrhosis in Essentials from the Golden Cabinet was retrieved,and the proposed standard of literature evaluation was used to evaluate the clinical research literatures and documents of case reports in order to cirrhosis TCM syndrome types in modern clinical environment. Results： It was unequivocal that there were 106 articles in the clinical research literatures on cirrhosis,and 113 individual cases of experience,and the following formulas were in common use,such as Rhubarb and Eupolyphaga Pill,Turtle Shell Decocted Pill,Stephania Root and Semen Zanthoxyli and Lepidium and Rhubarb Pill,Decoction for Removing Blood Stasis. Conclusion： The syndrome types in Rhubarb and Eupolyphaga Pill,Turtle Shell Decocted Pill,Stephania Root and Semen Zanthoxyli and Lepidium and Rhubarb Pill,Decoction for Removing Blood Stasis are probably the main symptoms of liver cirrhosis in the modern clinical environment.