生胃散联合温针灸对慢性萎缩性胃炎的疗效以及对血清胃蛋白酶原水平的影响

Clinical Efficacy of Shengwei Prescription Combined with Warming Acupuncture on Chronic Atrophic Gastritis and It's Effect on Serum Pepsinogen

目的:探讨生胃散联合温针灸对慢性萎缩性胃炎(CAG)的临床疗效及对血清胃蛋白酶原的影响,研究中医药的作用机制与优势。方法:选取慢性萎缩性胃炎患者80例,采用随机对照单盲法,分为观察组跟对照组,每组各40例,其中观察组使用生胃散加减联合温针灸共同治疗,对照组采用胃复春治疗,治疗4个月后,对比2组之间患者的临床疗效、胃镜下胃粘膜炎症、肠上皮化生、异型增生改善程度以及血清胃蛋白酶原治疗前后水平。结果:治疗组经过治疗后,在粘膜炎症、腺体萎缩、肠上皮化生、异型增生评分上,较治疗前有显著改善,结果有显著差异(P<0.05)。治疗后2组比较,治疗组在胃黏膜炎症、肠上皮化生、异型增生、血清胃蛋白酶原水平改善方面明显优于对照组,结果有显著差异(P<0.05)。结论:生胃散联合温针灸发对慢性萎缩性胃炎具有较理想的临床疗效,值得临床推广。

Objective： To investigate the clinical effect of Shengwei prescription combined with warming Acupuncture on chronic atrophic gastritis （CAG） and its effect on pepsinogen, and to study the mechanism and advantages of traditional Chinese medicine. Methods： Using randomized controlled blind method, 80 cases with CAG were randomly divided into treatment group and control group, each including 40 cases. The treatment group received Shengwei prescription combined with Warming Acupuncture, and the control group received Chinese patent medicine Weifuchun. After four months, compared the two groups＇ clinical effects, endo- scopic gastric mucosal inflammation, intestinal metaplasia, heterogenesis improvement and serum pepsinogen before and after the treatment. Results： After the treatment, the treatment group＇s scores of mucosal inflammation, gland atrophy, intestinal metaplasia, heterogenesis were obviously improved with statistically difference （P 〈 0. 05）, which showed significant difference compared with the control group （P 〈 0. 05 ） . Conclusion： Shengwei prescription combined with warming acupuncture have ideal effect on chronic atrophic gastritis, deserving further research and clinical promotion.