姜黄素治疗结直肠癌研究进展

Research Progress on Curcumin in Treatment of Colorectal Cancer

姜黄素治疗结直肠癌的作用体现在以下两个方面:(1)抗炎;(2)抗肿瘤。其中对STAT3、Notch1等信号通路的调节是姜黄素抑制肿瘤细胞增殖,诱导细胞凋亡的主要机制;同时通过恢复肿瘤抑制细胞活性,进而抑制肿瘤细胞生长。但姜黄素存在着生物利用度差的缺陷,仍需对其药物载体进行深入研究。

The roles of Curcumin in treatment of colorectal cancer are as the followings：（1） Anti-inflammatory;（2） Anti-tumor.The regulation of STAT3,Notch1 and other signaling pathways is the main mechanism in which Curcumin inhibits the proliferation of tumor cells and induces apoptosis.At the same time,it restores tumor cell growth by restoring the detailed cell activity of tumor.However,Curcumin has the disadvantage of poor bioavailability,and its drug carrier needs to be further studied.