摘要
姜黄素治疗结直肠癌的作用体现在以下两个方面:(1)抗炎;(2)抗肿瘤。其中对STAT3、Notch1等信号通路的调节是姜黄素抑制肿瘤细胞增殖,诱导细胞凋亡的主要机制;同时通过恢复肿瘤抑制细胞活性,进而抑制肿瘤细胞生长。但姜黄素存在着生物利用度差的缺陷,仍需对其药物载体进行深入研究。
The roles of Curcumin in treatment of colorectal cancer are as the followings:(1) Anti-inflammatory;(2) Anti-tumor.The regulation of STAT3,Notch1 and other signaling pathways is the main mechanism in which Curcumin inhibits the proliferation of tumor cells and induces apoptosis.At the same time,it restores tumor cell growth by restoring the detailed cell activity of tumor.However,Curcumin has the disadvantage of poor bioavailability,and its drug carrier needs to be further studied.
作者
肖遥
江滨
XIAO Yao1 ,JIANG Bin2(1. Nanjing University of Chinese Medicine, Nanjing Jiangsu China 210046; 2. Nanjing Hospital of Traditional Chinese Medicine, Nanjing Jiangsu China 21000)
出处
《中医学报》
CAS
2018年第2期207-209,共3页
Acta Chinese Medicine
基金
2015年度江苏省南京市医学科技发展项目(ZKX15040)
2015江苏省人力资源和社会保障厅组织"六大人才高峰"第十二批高层次人才选拔培养项目(WSW069)
2015年度江苏省第四期"333工程"科研项目资助计划项目