红细胞存储损伤影响因素及生物标志的研究进展

Research progress on influencing factors and biomarkers of RBCs storage lesion

红细胞（red blood cells,RBCs）存储损伤（storage lesion）是多方面因素综合作用的结果,涉及多层面的生物现象。献血者变异、RBCs制备和RBCs存储过程均会影响存储RBCs的质量,导致相同存储时间RBCs的保存质量有所不同,进而影响RBCs临床输注效果。如何评价存储RBCs的质量也是我们一直关注的焦点,近年来随着科学技术的不断发展,RBCs存储损伤的代谢标志、蛋白标志、RNA标志和衰亡（eryptosis）等研究开创了存储损伤研究的新局面。

Red blood cells（RBCs） storage lesion is the combination result of many factors,involving multiple biological phenomenon. Variability of blood donor,RBCs preparation and RBCs storage process will affect the quality of stored RBCs,result in different preserve quality of RBC during the same storage time,thereby affecting the clinical infusion effect of RBCs.How to evaluate the quality of stored RBCs is also the focus of our attention. In recent years,with the development of science and technology in recent years,the study of metabolites,protein,RNA and eryptosis biomarkers during RBCs storage lesion creates a new situation in storage lesion research.