摘要
独活寄生汤是应用于骨伤科类疾病的常用方剂,治疗膝骨性关节炎尤为广泛。笔者总结近十余年中外文献,对其治疗的作用机制进行分类、总结,发现该方剂不仅可以抑制炎症因子,影响氧化应激指标,而且在抑制基质金属蛋白酶、抑制软骨细胞凋亡、增加软骨胶原含量、影响微小RNA表达等方面发挥作用。随着其作用机制研究的不断深入,不但能拓宽该方剂的使用范围,而且能更清晰地指导临床医师精准用药。
Duhuo Jisheng Decoction is a common formula for curingorthopedic diseases, which is particularly extensive in the treatment of knee osteoarthritis. The author summarizes literatures at home and abroad in the nearly ten years, classifies and sums up the treatment mechanism, and finds that the formulae not only can inhibit inflammatory cy- tokines and affects oxidative stress indicators, but also plays an important role in the inhibition of matrix metallopro- teinase, inhibition of chondrocyte apoptosis, increasing cartilage collagen content and influencing the expression of mi- croRNA. With the further research of the mechanism, it can not only broaden the use of the formula, but also guide clinicians to use precise formula more clearly.
作者
苏晓琳
王江威
赵婉
杨炳友
匡海学
王秋红
SU Xiaolin;WANG Jiangwei;ZHAO Wan;YANG Bingyou;KUANG Haixue;WANG Qiuhon(Key Laboratory of North Medicine Base and Application, Ministry of Education, Heilongjiang University of Chinese Medicine Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material Bases, Heilongjiang Province, Harbin 150040, China;College of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Province, Guangzhou 510006, China)
出处
《中国医药导报》
CAS
2018年第7期36-39,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81773904
81473351)
黑龙江中医药大学科研基金项目(201720)
关键词
膝骨性关节炎
独活寄生汤
作用机制
研究进展
Knee osteoarthritis
Duhuo Jisheng Decoction
Mechanism
Research progress