独活寄生汤治疗膝骨性关节炎作用机制的现代药理学研究进展

Modern pharmacology research progress on the mechanism of Duhuo Jisheng Decoction in the treatment of knee osteoarthritis

独活寄生汤是应用于骨伤科类疾病的常用方剂,治疗膝骨性关节炎尤为广泛。笔者总结近十余年中外文献,对其治疗的作用机制进行分类、总结,发现该方剂不仅可以抑制炎症因子,影响氧化应激指标,而且在抑制基质金属蛋白酶、抑制软骨细胞凋亡、增加软骨胶原含量、影响微小RNA表达等方面发挥作用。随着其作用机制研究的不断深入,不但能拓宽该方剂的使用范围,而且能更清晰地指导临床医师精准用药。

Duhuo Jisheng Decoction is a common formula for curingorthopedic diseases, which is particularly extensive in the treatment of knee osteoarthritis. The author summarizes literatures at home and abroad in the nearly ten years, classifies and sums up the treatment mechanism, and finds that the formulae not only can inhibit inflammatory cy- tokines and affects oxidative stress indicators, but also plays an important role in the inhibition of matrix metallopro- teinase, inhibition of chondrocyte apoptosis, increasing cartilage collagen content and influencing the expression of mi- croRNA. With the further research of the mechanism, it can not only broaden the use of the formula, but also guide clinicians to use precise formula more clearly.