慈芦消肿饮治疗乳腺癌术后上肢淋巴水肿疗效观察

Clinical study on the effect of ciluxiaozhongyin on upper limb lymphedema after breast cancer surgery

目的观察自拟慈芦消肿饮治疗乳腺癌术后上肢淋巴水肿的临床疗效。方法选取2016年8—12月蚌医一附院中医肿瘤科、肿瘤外科及放疗科60例乳腺癌术后上肢淋巴水肿的患者,采用简单随机分组法分为对照组及治疗组,每组各30例。对照组给予地奥司明0.45 g口服,2次/d,患肢功能锻炼及局部按摩;治疗组在对照组治疗基础上给予慈芦消肿饮,水煎服每日2次,早晚分服,治疗4周。采用t检验及秩和检验观察2组在上肢水肿、上肢疼痛的变化及中医临床疗效的改变。结果 2组上肢水肿变化比较,对照组总有效率56.7%,治疗组总有效率83.3%,治疗组明显优于对照组,差异有统计学意义(P<0.01);2组上肢疼痛改善情况比较,对照组总有效率53.3%,治疗组总有效率86.7%,治疗组明显优于对照组,差异有统计学意义(P<0.05);治疗前2组中医证候积分比较,差异无统计学意义(P>0.05),治疗后2组证候积分均低于同组治疗前,差异有统计学意义(P<0.05),治疗组治疗后证候积分下降更明显,与对照组治疗后相比,差异有统计学意义(P<0.05)。结论慈芦消肿饮能明显促进乳腺癌术后上肢淋巴水肿消退,减轻疼痛,提高患者生活质量。

Objective To observe the effect Ciluxiaozhongyin on upper limb lymphedema of patients with breast cancer after surgery. Methods A total of 60 patients with upper limb lymphedema after breast cancer surgery were selected in the First Affiliated Hospital of Bengbu Medical College, Chinese medicine oncology department, tumor surgery and radio- therapy department from August, 2016 to December, 2016, which were divided into the observation group and the treat- ment group by simple random grouping, with 30 cases in each group. And 30 cases in the observation group were given Diosmin 0.5 orally two times a day, limb function exercise and local massage ; the treatment group of 30 cases in the ob- servation group on the basis of such treatment were given Ciluxiaozhongyin, decoction two times a day morning and eve- ning for 4 weeks. T test and rank sum test were used to observe the changes of upper limb edema, upper limb pain and clinical curative effect of TCM in the two groups. Results Compared with the observation group with 56.7% efficiency in upper limb edema, the treatment group with 83.3 % efficiency was improved significantly （P 〈 0, 01 ） ; Compared with the observation group, with 53.3% efficiency, in upper limb pain the treatment group with 86.7% efficiency was better, the difference was of significance in statistics science （ P 〈 0.05 ） ; Without treatment the difference in comparison of TCM syndrome integral was not of significance in statistics science （ P 〉 0.05 ）, while after treatment the result is oppo- site （P 〈 0.05 ）. TCM syndrome integral of treatment declined more apparently than the observation group, with statisti- cal significance （P 〈 0.05）. Conclusion Ciluxiaozhongyin can significantly promote breast cancer postoperative upper limb lymphedema, relieve the pain, and improve the quality of life of patients.