丹瓜方对痰瘀型2型糖尿病患者血清TGF-β1、ox-LDL的影响

Effect of Dangua Recipe on Serum TGF-β1 and Ox-LDL in Type 2 Diabetic Patients with Phlegm and Blood Stasis

目的观察丹瓜方对痰瘀型2型糖尿病患者血清TGF-β1、ox-LDL的影响。方法将144例痰瘀型2型糖尿病患者随机分为观察组和对照组各72例。对照组采用常规降糖、降压、调脂治疗,观察组在对照组治疗基础上联合丹瓜方治疗,疗程均为4周。观察2组治疗前后FBG、2h PG、TC、TG、LDL、TGF-β1、ox-LDL及证候积分的变化。结果观察组剔除3例,对照组剔除2例。与对照组比较,观察组治疗后2h PG、TC、LDL、TGF-β1、ox-LDL水平及证候积分明显下降(P<0.05)。结论丹瓜方可改善痰瘀型2型糖尿病患者糖脂代谢,可抑制糖尿病炎症反应并减轻血管内皮损伤,具有抗动脉粥样硬化的作用。

Objective： To observe the effect of Dangua Recipe on serum TGF-beta 1 and ox-LDL in type 2 diabetic patients with phlegm and blood stasis. Methods： 144 cases of type 2 diabetes with phlegm and blood stasis were randomly divided into two groups：the observation group and the control group, each of 72 cases. The control group was treated with conventional hypoglycemic and antihypertensive therapy, and the observation group combined with the treatment of Dangua Recipe. The courses of treatment were 4 weeks. The levels of FBG, 2 h PG, TC, TG, LDL, TGF-beta 1, ox-LDL and syndrome scores of the 2 groups were observed before and after treatment. Results： 3 cases were removed from the observation group. 2 cases were removed in the control group. Compared with the control group, the levels of 2 h PG, TC, LDL, TGF-beta 1, ox-LDL and syndrome scores in the observation group were significantly decreased（P〈0.05）. Conclusion： Dangua Recipe can improve glycolipid metabolism in type 2 diabetic patients with phlegm and blood stasis, inhibit the inflammatory response of diabetes and reduce vascular endothelial damage. Dangua Recipe has the effect of anti arteriosclerosis.