网络化认知行为疗法MoodGYM对青少年及大学生抑郁症状干预效果的Meta分析

The effect of internet-based cognitive behavior therapy MoodGYM on adolescents and college students with depression symptoms： a Meta-analysis

目的系统评价网络化认知行为疗法MoodGYM对青少年和大学生抑郁症状的干预效果。方法计算机检索Web of Science、PubMed、Cochrane Library、Embase、中国生物医学文献数据库、巾国期刊全文数据库、万方数据库中关于MoodGYM用于青少年和大学生抑郁症状的随机对照试验和临床对照试验。检索时限均为建库至2017年1月22日。按照纳入排除标准由2人独立进行文献的筛选、资料提取和质量评价后，采用RevMan5．3软件进行Meta分析。结果共纳入7篇研究，1632个研究对象。Meta分析结果显示，MoodGYM干预组的抑郁、焦虑、负性自动思维评分低于对照组，差异有统计学意义（标准化均数差=-0．45，95％CI-0．82- -0．07，P=0．02；加权均数差=-7．36，95％CI- 11．88- -2．85，P=0．001；加权均数差=-18．06，95％CI -26．44- -9．68，P〈0．01）。结论MoodGYM有助于改善青少年和大学生的抑郁、焦虑及自动负性思维症状，但这一结论需要大样本高质量的随机对照试验进一步予以验证。

Objective To evaluate the effect of internet-based cognitive behavior therapy MoodGYM on adolescents and college students with depression symptoms through Meta-analysis. Methods Databases as Web of Science, PubMed, Cochrane Library, Embase, Chinese Biomedical Database, China National Knowledge Internet and Wanfang were searched from their establishment to January 2017 for collecting randomized controlled trails and clinical controlled trails about MoodGYM for adolescents and college students with depression symptoms. Two reviewers independently selected studies, extracted data and assessed risk of bias. RevMan 5.3 software was used to perform Meat-analysis. Results Seven studies involving 1 632 participants were included. The results of Meta-analysis showed that the score of depression, anxiety and negative automatic thoughts in MoodGYM arm was lower than control arm, the statistic results： standardized mean difference=-0.45, 95% CI-0.82- -0.07, P=0.02; mean difference=-7.36, 95%CI-11.88- -2.85, P=0.001; mean difference=- 18.06, 95%CI-26.44- -9.68, P〈0.01, the difference between experiment arm and control arm was significant. Conclusions MoodGYM can contribute to improve depression, anxiety and negative automatic thought of adolescents and college students. This intervention should be further examined by high-quality, large-sample randomized controlled trails.