5-羟色胺转运体基因启动子区基因多态性与原发性早泄关系研究进展

Correlation of 5-hydroxytryptamine transporter gene-linked polymorphic region with lifelong premature ejaculation: Progress in studies

早泄是现今最常见的男性性功能障碍性疾病之一,对患者及其伴侣间的性生活满意度产生严重负面影响。原发性早泄是最常见的早泄类型之一,也是目前研究的热点,其病因和发病机制尚不明确,遗传学因素被认为与原发性早泄联系紧密。研究表明5-羟色胺转运体基因在原发性早泄的发生和发展过程中发挥着重要作用。近年来,5-羟色胺转运体基因启动子区基因多态性备受人们关注。本文主要就5-羟色胺转运体基因启动子区基因多态性与原发性早泄关系的研究进行综述。

Premature ejaculation （PE）, as one of the most common male sexual dysfunctions, has a serious negative impact on the sexual satisfaction of the patients and their sexual partners. Lifelong PE is a most common type and a current focus of research as well. The etiology and pathogenesis of this disease are not yet clear and genetic factors are considered to be closely related to lifelong PE. Studies show that the 5-hydroxytryptamine transporter （5-HTT） gene plays an important role in the development and progression of lifelong premature ejaculation and the 5-HTT-linked polymorphic region （5-HTTLPR） has attracted much attention in recent years. This article presents an overview on the correlation between 5-HTTLPR and lifelong PE.