经皮射频消融术与开腹手术治疗原发性中小肝癌的疗效对比

Comparative analysis of curative effect of percutaneous ra-diofrequency ablation and open resection for primary small and medium liver cancer

目的:探讨经皮肝癌射频消融术与开腹手术切除治疗直径≤5 cm的原发性肝癌的疗效对比。方法:回顾性分析2009年1月—2014年12月原发性肝癌患者255例,其中肿瘤≤5 cm 130例,分为观察组(经皮射频消融术)63例和对照组(开腹手术)67例,对比分析两组疗效差异。结果:观察组术后1、3、5年总体生存率为93.7%、69.8%、15.9%,对照组术后1、3、5年总体生存率为92.5%、74.6%、17.9%,两组之间生存期无明显差异,观察组术后1、3、5年无瘤生存期为81.0%、33.3%、1.6%;对照组术后1、3、5年无瘤生存期为88.1%、53.7%、10.4%,两组之间差异有统计学意义。结论:经皮射频消融术相比开腹手术切除治疗原发性中小肝癌具有相近的远期治疗效果,开腹手术的复发率低于射频消融术,经皮射频消融术创伤小、术后并发症少、住院时间短。

Objective： To investigate the effects of radiofrequency ablation and hepato-recetion in the treatment of less than 5 cm of primary liver cancer. Methods： A retrospective analysis from January 2009 to December 2014 in Department of hepatobiliary surgery, Chifeng Hospital treated 255 cases of primary liver cancer patients, including 130 cases of tumors less than 5 cm. They were divided into treatment group （percutaneous radiofrequency ablation） and control group （open surgery group）, To get evaluation of effects preliminarily, aH patients were followed up with ultrasonography and blood tests, etc. Results： Percutaneous radiofrequency ablation group after 1, 3, 5 year overall survival rate was 93.7%, 69.8%, 15.9%, Patients in the control group were 1, 3 and 5 years overall survival rate was 92.5%, 74.6%, 17.9%.Two groups had no significant difference between the survival period, percutaneous radiofrequency ablation group after 1 and 3 and 5 years disease-free survival was 81%, 33.3%, 1.6%; laparotomy in the control group after 1, 3 and 5 years disease-free survival was 88.1%, 53.7%, 10.4%, the difference was statistically significant between the two groups. Conclusion： Compared with the operation group, the radiofrequency ablation group recovered faster and had less complications, and the difference between the two groups was statistically significant. Compared with open operation group, primary percutaneous radiofrequency ablation for primary small and medium liver cancer has similar long-term therapeutic effect. Percutaneous radiofrequency ablation has less trauma, less complications and shorter hospital stay than that of the control group.