嗜碱性粒细胞百分比与慢性肾脏病关系的回顾性队列研究

Association between basophils percentage and chronic kidney disease:a retrospective cohort study

目的探讨嗜碱性粒细胞百分比对慢性肾脏病(CKD)发病的影响。方法从"山东多中心健康管理纵向观察队列"中抽取年龄20岁以上、至少接受2次健康体检、初次体检未患CKD且无重要指标缺失者建立回顾性队列。将研究对象按基线嗜碱性粒细胞百分比的四分位数分为4组(Q1、Q2、Q3、Q4),应用Cox回归模型分析嗜碱性粒细胞百分比与CKD发生的关联。结果研究队列包含17 173人,男10 614人,女6 559人。研究期间共随访42 204.04人年,新发CKD 737例,发病密度为17.46/1 000人年。多元Cox回归模型结果显示,在调整年龄和性别后,以Q1为参照组,Q2、Q3、Q4三组嗜碱性粒细胞百分比的HR(95%CI)分别为0.990(0.776~1.263)、1.235(1.011~1.509)、1.352(1.099~1.663);进一步调整体质量指数、高血压、糖尿病、血尿酸、血肌酐、血尿素氮、总胆固醇、低密度脂蛋白胆固醇、甘油三酯后,以Q1组为参照组,Q2、Q3、Q4的HR(95%CI)分别为0.966(0.740~1.262)、1.225(0.985~1.525)、1.355(1.077~1.705)。结论嗜碱性粒细胞百分比升高是CKD发生的独立危险因素。

Objective To explore the effect of basophils percentage on the incidence of chronic kidney disease（ CKD）.Methods A retrospective cohort was conducted using the data from Shandong Multi-center Longitudinal Cohort for Health Management. All subjects ≥20 years old who were free of CKD at baseline and accepted at least two annually physical examinations were selected. The participants were divided into four groups（ denoted by Q1,Q2,Q3,Q4） according to quartiles of basophils percentage at baseline. Cox regression models were used to identify the association between basophils percentage and CKD. Results The cohort consisted of 17 173 subjects,including 10 614 males and6 559 females. There were 737 CKD cases occurring during the 42 204.04 person-years following up,resulting in an incidence of 17.46/1 000 person-year. The multivariate Cox regression model with adjusting age and gender showed that HRs（ 95%CI） of basophils percentage to CKD for the groups of Q2,Q3 and Q4（ with Q1 as reference group） were0.990（ 0.776-1.263）,1.235（ 1.011-1.509） and 1.352（ 1.099-1.663） respectively. Furthermore,after all other related variables such as body mass index,hypertension,diabetes,blood uric acid,serum creatinine,blood urea nitrogen,total cholesterol,low density lipoprotein cholesterol and triglyceride were adjusted,the HRs（ 95%CI） of Q2,Q3 and Q4were 0.966（ 0.740-1.262）,1.225（ 0.985-1.525） and 1.355（ 1.077-1.705）,respectively. Conclusion Increasing basophils percentage is an independent risk factor of CKD.