期刊文献+

髓过氧化物酶阳性间质性肺炎胸部CT研究

Chest CT study in patients with interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody
原文传递
导出
摘要 目的探讨髓过氧化物酶阳性间质性肺炎(interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody,MPO-IP)的胸部高分辨率CT特点。方法回顾分析MPO-IP患者胸部高分辨率CT纤维化和肺气肿程度,并与同期收治的特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)病例作比较。结果 2014年7月至2016年3月期间,各有10例患者分别被诊断为MPO-IP和IPF,两组间肺气肿无明显差异。MPO-IP患者中8例影像学表现为普通性间质性肺炎(usual interstitial pneumonia,UIP),与IPF组比较,在气管分叉层面存在显著差异,肺纤维化评分低于IPF患者。结论 MPO-IP影像学上以UIP为主,MPO-IP(UIP)纤维化程度较IPF轻,肺气肿以间隔旁肺气肿和小叶中心型肺气肿为主。 Objective To investigate the characteristics on chest high-resolution computed tomography (HRCT) of patients with interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody (MPO-IP). Methods The extent of fibrosis and subtypes of emphysema on HRCT of MPO-IP patients were retrospectively analyzed and compared with idiopathic pulmonary fibrosis (IPF) cases admitted in the same period. Results From July 2014 to March 2016, 10 patients was diagnosed with IPF and 10 patients was diagnosed with MPO-IP. Emphysema was not different between two groups. Among the MPO-IP patients, 8 patients presented with a usual interstitial pneumonia (UIP) pattern. There existed statistical difference in the bronchial bifurcation level, the fibrosis score of lungs in the MPO-IP patients presented with UIP was lower than that in the IPF patients. Conclusions UIP is the predominant radiologic type of MPO-IP patients. Fibrosis in IPF is more serious than that in MPO-IP with UIP. Paraseptal and centrilobular emphysema are main forms in MPO-IP patients.
作者 李学任 刘斌 丁梦江 彭守春 魏路清 LI Xueren~, LIU Bin~, DING Mengjiang2, PENG Shouchun1, WEI Luqing1(1. Department of Respiratory and Critical Care Medicine, Pin, in Hospital, Lo~stics University of the Chinese People's Armed Police Forces, Tianjing 300162, P. R. China 2. Tianfin Provincal Corps Hospital of Chinese People's Armed Police Force, Tianfing 300162, P. R. Chin)
出处 《中国呼吸与危重监护杂志》 CAS CSCD 北大核心 2018年第2期183-186,共4页 Chinese Journal of Respiratory and Critical Care Medicine
基金 国家自然基金项目(81600051) 武警后勤学院基础研究项目(WHJ2016019)
关键词 间质性肺疾病 MPO阳性 特发性肺纤维化 肺气肿 高分辨率CT Interstitial pneumonia Positive myeloperoxidase antineutrophil cytoplasmic antibody Idiopathicpulmonary fibrosis Emphysema Chest high-resolution computed tomography
  • 引文网络
  • 相关文献

参考文献2

二级参考文献12

  • 1中华医学会风湿病学分会.显微镜下多血管炎诊治指南(草 案)[J].中华风湿病学杂志,8:564-565.
  • 2ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Eur Respir J,2002,19:794-796.
  • 3Jennette JC,Falk R J,Andrassy K,et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum,1994,37:187-192.
  • 4Bhanji A,Karim M. Pulmonary fibrosis-an uncommon manifestation of anti-myeloperoxidase-positive systemic vasculitis?. NDT Plus,2010,3:351-353.
  • 5Eschun GM,Mink SN,Sharma S. Pulmonary Interstitial Fibrosis as a presenting manifestation in perinuclear antineutrophilic cytoplasmic antibody microscopic polyangiitis. Chest,2003,123:297-301.
  • 6Birnbaum J,Danoff S,Askin FB,et al. Microscopic polyangiitis presenting as a “ pulmonary-muscle” syndrome:is subclinical alveolar hemorrhage the mechanism of pulmonary fibrosis?. Arthritis Rheum,2007,56:2065-2071.
  • 7Launay D,Souza R,Guillevin L,et al. Pulmonary arterial hypertension in ANCA-associated vasculitis. Sarcoidosis Vasc Diffuse Lung Dis,2006,23:223-228.
  • 8Tzelepis GE,Kokosi M,Tzioufas A,et al. Prevalence and outcome of pulmonary fibrosis in microscopic polyangiitis. Eur Respir J,2010,36:116-121.
  • 9Foucher P,Heeringa P,Petersen AH,et al. Antimyeloperoxidaseassociated lung disease. An experimental model. Am J Respir Crit Care Med,1999,160:987-994.
  • 10Idiopathic pulmonary fibrosis: diagnosis and treatment. International Consensus Statement. American Thoracic Society ( ATS ), and the European Respiratory Society (ERS). Am J Respir Crit Care Med, 2000,161:646-664.

共引文献112

;
使用帮助 返回顶部