丙种球蛋白治疗小儿重型手足口病疗效观察

Effect of gamma globulin on children with severe hand-foot-mouth disease

目的观察丙种球蛋白治疗小儿重型手足口病(HFMD)的临床疗效。方法选取2015年10月—2017年2月湖南省儿童医院收治的86例重型HFMD患儿资料进行回顾性分析,根据治疗方式的不同分为丙种球蛋白组和常规治疗组,每组患儿均为43例。常规治疗组患儿采取常规用药治疗;丙种球蛋白组患儿在常规治疗基础上静脉注射丙种球蛋白1 g·kg^(-1)·d^(-1),连用2 d。比较两组患儿的治愈时间、住院时间以及临床疗效。结果丙种球蛋白组患儿的治愈时间和住院时间明显短于常规治疗组[治愈时间(d):6.54±2.21比9.47±3.45,住院时间(d):11.83±1.48比15.93±2.35];丙种球蛋白组患儿的总有效率明显高于常规治疗组[95.35%(41/43)比55.81%(24/43)],两组比较差异均有统计学意义(均P<0.05)。结论应用丙种球蛋白治疗重型HFMD患儿,能有效减轻患儿的临床症状,缩短住院时间,提高临床疗效。

Objective To evaluate the clinical efficacy of gamma globulin in the treatment of severe handfoot-mouth disease in children. Methods From October 2015 to February 2017, 86 severe hand-foot-mouth disease patients in Children＇s Hospital of Hunan Province were admitted and made a retrospectively analysis. According to the different methods of treatment, it was divided into the gamma globulin group and routine treatment group, each group were 43 cases of children. The children received the conventional medication treatment in the routine treatment group. In gamma globulin group, the children had intravenous injection gamma globulin（1 g·kg^（-1）·d^（-1）,for 2 days） based on routine treatment. The cure time, hospitalization time and clinical effect were compared between the two groups. Results The cure time and hospitalization time of children in the gamma globulin group were significantly shorter than those in the routine treatment group [The cure time（d）： 6.54±2.21 vs. 9.47±3.45, the hospitalization time（d）： 11.83±1.48 vs. 15.93±2.35]. The total effective rate of the children in the gamma globulin group was significantly higher than that in the routine treatment group [95.35%（41/43） vs. 55.81%（24/43）], and the difference between the two groups were statistically significant（all P〈 0.05）. Conclusions Gamma globulin can effectively relieve the clinical symptoms of children with severe HFMD, shorten the time of hospitalization and improve the clinical effectiveness.