摘要
基于肿瘤细胞内外还原性环境而设计合成还原敏感型肿瘤靶向药物得到人们的关注。小分子药物在偶联时由于化学结构发生改变,导致药物活性受到影响。综述了还原敏感型小分子药物递送的释放机理及应用,阐明了小分子药物完整释放的机理。
The application of the reduction-sensitive small-molecule drug delivery systems designed based on a significant difference between the reductive environments inside and outside tumor cell have attracted much attention. However, the chemical properties of small-molecule drug are changed due to the chemical bond linker,and these changes influence the small-molecule drug activity. The paper reviewed current research status of the release mechanism and application of the reduction-sensitive small-molecule drug delivery systems.
作者
李鹏熙
程旭
陈本寿
李东红
杨玲玲
LI Peng-xi;CHENG Xu;CHEN Ben-shou;LI Dong-hon;YANG Ling-ling(Chongqing Chemical Industry Vocational College, Chongqing 400020, China;The 2nd Department of Research Institude of Surgery, Third Military Medical University, Chongqing 400042, China;Department of Occupational Health, Third Military Medical University, Chongqing 400042, China)
出处
《精细化工中间体》
CAS
2017年第5期15-18,共4页
Fine Chemical Intermediates
基金
重庆市基础与前沿研究计划项目(cstc2016jcyj A0075)
重庆市长寿区科技计划项目(CS2017006)
关键词
小分子药物
还原敏感型
双硫键
药物递送
small-molecule drug
reduction-sensitive
disulfide bond
drug delivery
