空气氧化法合成丙硫菌唑

Preparation of Prothioconazole by Air Oxidation Process

以2-(1-氯环丙基)-1-(2-氯苯基)-3-(1,2,4-三唑烷-5-硫酮-1-基)-2-丙醇为原料,在甲基叔丁基醚溶剂中,m(原料)∶v(甲基叔丁基醚)=1∶5,空气作为氧化剂,常温反应6 h,一锅法合成丙硫菌唑,开发出一条操作简便、反应绿色的丙硫菌唑合成工艺,为工业化生产提供了思路。产品经质谱和核磁共振氢谱碳谱确证。

Prothioconazole was synthesized using 2-（1-chlorcyclopropyl）-1-（2-chlorphenyl）-3-（1,2,4-triazolidin-5-thiono-1-yl）-2-propanol as the starting material via an one-pot air oxidation process in methyl tert-butyl ether. The reaction proceeded at 25℃ for 6 h. This simple and green preparation method could be applied for industrial production. Structure of the product was characterized by MS and NMR spectrum.