突触后支架蛋白在病理性疼痛中的作用

A review on the progresses of postsynaptic density scaffolding protein in pathological pain

背景突触后支架蛋白是突触后致密物（postsynaptic density，PsD）中的主要功能成分。作为兴奋性谷氨酸能神经元突触后膜上的细胞骨架蛋白，在谷氨酸受体和多种激酶的信号转导中具有重要作用。目的阐述突触后支架蛋白在病理性疼痛发生和发展过程中的作用及机制。内容就PSD家族中的重要支架蛋白PSD-95、Homer、Shank在神经病理性疼痛（neuropathic pain，NPP）、炎性痛及癌性痛中的作用研究进展进行综述。趋向为临床病理性疼痛的研究和治疗提供新的思路和方向。

Background Postsynaptic density （PSD）, a dense anchoring and scaffolding protein, plays a critical role in regulating the interactions between glutamate receptors and associated signaling enzymes. Objective To illuminate the role and mechanism of PSD in the development and progression of pathological pain. Content This paper overview recent progresses of research in the mechanism of PSD-95, Homer and Shank proteins, three major scaffolding molecules at PSD in chronic neuropathic pain （NPP）, inflammatory and cancer pain. Trend Here, we provide new information related to the role of PSD scaffolding protein in the targeted clinical therapy of neural pathological pain.