四磨汤口服液治疗小儿功能性消化不良临床效果观察

Clinical observation on the treatment of functional dyspepsia in children by Simotang Oral Liquid

目的探讨四磨汤口服液治疗小儿功能性消化不良(FD)的临床效果。方法收集宜川县人民医院2016年1月—2016年12月收治的小儿FD患者120例,按照随机数字表法分为观察组和对照组,每组60例,两组均给予常规治疗,观察组在常规治疗基础上给予四磨汤口服液治疗,1~3岁一次3~5 m L,一日3次,疗程2 d;4~12岁一次10 m L,一日3次,疗程3~5 d;对照组在常规治疗基础上给予安慰剂治疗,安慰剂形状、色泽、味道等与四磨汤口服液相同,服用周期、次数及剂量均与四磨汤口服液相同,两组患者均治疗2周,评价治疗效果以及检测血浆P物质和胃动素水平。结果观察组治疗有效率为98.33%,高于对照组的86.67%(P<0.05)。治疗前胃动素水平及血浆P物质组间对比无统计学意义;治疗后两组血浆P物质和胃动素水平均升高,并且观察组上升幅度大于对照组,差异有统计学意义(P<0.05)。治疗过程中对照组发生恶心、呕吐病例4例,发生率为6.67%;观察组发生1例,发生率为1.67%,差异无统计学意义。结论四磨汤口服液联合常规治疗措施可以明显提高治疗效果,并且可能通过提升血浆P物质和胃动素水平起作用。

Objective To investigate the clinical effect of Simotang Oral Liquid in the treatment of functional dyspepsia（FD） in children. Methods 120 cases of pediatric FD patients admitted in our hospital from January 2016 to December 2016 were divided into observation group and control group according to the random number table method. Sixty patients in each group were given routine treatment, and the observation group was treated Based on the treatment of oral administration of Simotang Oral Liquid, the control group in the conventional treatment based on the placebo treatment, evaluation of treatment and the detection of plasma substance P and motilin levels. Results The effective rate was 98.33% in the observation group and 86.67% higher than that in the control group（P〈0.05）. There was no significant difference between the plasma substance P and the motilin level before treatment. After treatment, the levels of plasma substance P and motilin in the two groups were higher than those in the control group（P〈0.05）. In the course of treatment, nausea and vomiting occurred in the control group. The incidence was 6.67%, the observation group occurred in 1 case, the incidence was 1.67%. Conclusion Simotang Oral Liquid combined with conventional treatment can significantly improve the therapeutic effect, and may play a role in improving the plasma substance P and motilin levels.