血清生长分化因子15水平与急性冠脉综合征患者非靶血管斑块进展的相关性分析

Correlation of serum growth differentiation factor-15 level and atherosclerotic progression of non-culprit coronary lesions in patients with acute coronary syndrome

目的探讨急性冠脉综合征患者血清生长分化因子15(growth differentiation factor-15,GDF-15)水平与冠状动脉粥样非靶血管斑块进展的相关性。方法纳入2015年1月1日-2017年10月1日于解放军总医院心血管内科行冠状动脉造影的急性冠脉综合征(acute coronary syndrome,ACS)患者200例,测定所有患者GDF-15水平,并于患者入组1年后再次行冠状动脉造影,对前后两次冠状动脉造影进行定量冠状动脉造影分析。结果本研究失访者17例,失访率为8.50%,最终共183例ACS患者纳入分析。根据冠状动脉造影定量分析结果,斑块进展组及斑块非进展组分别为59例及124例,非靶血管斑块进展组血清GDF-15水平高于斑块非进展组[(1 227.36±193.11)mmo/L vs(1 024.90±173.84)mmo/L,P=0.037]。结论 ACS患者血清GDF-15水平与冠状动脉非靶血管斑块的进展相关,并可能成为预测非靶血管斑块进展的潜在生物标记物。

Objective To investigate the correlation of serum growth differentiation factor-15 （GDF-15） and atherosclerotic progression of non-culprit coronary lesions in patients with acute coronary syndrome （ACS）. Methods Total of 300 ACS patients who underwent coronary angiography in Chinese PLA General Hospital from January 2015 to October 2017 were selected in our study. Serum GDF- 15 and 1-year follow-up coronary angiography were assessed. Results In this study, 17 patients were lost to follow-up with the dropout rate of 8.50%, and totally 183 ACS patients were included. Patients were divided into plaque progression group （n=59） and non-progression group （n=124） according to quantitative coronary angiography （QCA）. The serum GDF-15 level was significantly higher in progression group than in non-progression group [（1 227.36 ± 193.11） mmo/L vs （1 024.90± 173.84）mmo/L, P=0.037]. Conclusion The level of serum GDF-15 in ACS patients is positively correlated with the progression of non-culprit coronary lesions, and it may be a potential biomarker for predicting the progression of non-culprit coronary lesions.