华法林药物基因组学研究与临床应用进展

Research and clinical application advances in the pharmacogenomics of warfarin

华法林是我国临床广泛应用的口服抗凝药物，其治疗窗窄，治疗剂量个体差异大，药效受多种因素影响，如基因多态性、年龄、饮食习惯等。如何个体化给药成为临床医生指导抗凝治疗工作的重要部分。近年国内外针对华法林遗传药物基因组学的研究屡见报道，已发现多种基因的多态性可影响华法林药效，本文将对几种华法林药物相关基闪的基因多态性与其临床应用进展进行综述。

Warfarin is widely used as an oral anticoagulant in clinic in China. It has narrow therapeutic index, large individual differences on dosage and the variability in warfarin dosage depends on many factors, including gene polymorphism, age, diet habits and so on. For clinicians, how to optimize the individual therapeutic regimen of warfarin is becoming a significant part of their work. In recent years, studies on genetic pharmacogenomics of warfarin are reported frequently. It is found that multiple gene polymorphisms can affect the efficacy of warfarin. We will introduce the gene polymorphism of some warfarin related genes and their effects on warfarin, and the advances of warfarin individual therapeutic regimen will also be discussed here.