血清胃蛋白酶原Ⅰ/Ⅱ及胃泌素17在体检人群中的表达差异

Expression differences of serum pepsinogen Ⅰ/Ⅱ and gastric secrete element 17 in the physical examination population

目的：检测体检人群中血清胃蛋白酶Ⅰ（PG-Ⅰ）、胃蛋白酶Ⅱ（PG-Ⅱ）、胃泌素17（G-17）含量,观察胃蛋白酶Ⅰ/胃蛋白酶Ⅱ（PG-Ⅰ/PG-Ⅱ）比值的变化,探讨血清胃蛋白酶原Ⅰ/Ⅱ及胃泌素17在体检人群中的表达差异.方法：收集我院体检中心2016年1～12月体检者血清7016例;检测PG-Ⅰ、PG-Ⅱ、G-17含量,计算PG-Ⅰ/PG-Ⅱ比值.结果：PG-Ⅰ、PG-Ⅱ、G-17和PG-Ⅰ/PG-Ⅱ的异常发生率无性别差异;与年龄有一定关系,年龄大于70岁的人群中,异常发生率明显高于低年龄组（P〈0.05）结论：血清PG-Ⅰ、PG-Ⅱ、G-17、及PG-Ⅰ/PG-Ⅱ的检测能够用于老年人和体检人群的胃病筛查,为胃肠镜筛查和胃病诊断提供依据.

Objective： To detect serum pepsinogen I （PG-I） , serum pepsinogen II （PG-I1） and gastric secrete element 17 （G-17） in the physical examination population, and observe the ratio of PG-I/PG-II, and discuss the expression differences ofserum PG-I/PG-II and G-17 in the physical examination population. Methods： 7016 cases of serum in the physical examination center of our hospital from January 2016 to December 2016 were collected; the contents ofPG - I, PG - II, G - 17, and calculate the ratio of PG-I/PG-II were detected. Results： There is no gender difference in the incidence of abnormal for PG-I, PG-II, G-17 and PG-I/PG-II; Certain relationship could be found in age, and the abnormal rate of more than 70-year-old crowd is significantly higher than that of the lower age group （P〈0.05） . Conclusion： Serum PG-I, PG-II, G-17, and PG-I/PG-II test can be used for the stomach disease screening for elderly and check-up crowd, providing basis for stomach trouble screening and stomach disease diagnosis.