联合检测高荧光细胞和CEA对恶性积液的诊断价值

Diagnostic value of combined detection of high-fluorescent cell and CEA for malignant hydrothorax or ascites

目的：探讨胸腹水中HF-BF％、HF-BF#和CEA的联合检测在良恶性胸腹腔积液鉴别诊断中的价值.方法：收集2014年11月至2016年12月胸腹水标本110例,其中恶性肿瘤53例（恶性组）,非恶性肿瘤57例（良性组）,进行胸腹水高荧光细胞绝对值（HF-BF#）及比率（HF-BF％）和CEA的测定,并对相关数据进行统计分析.结果：恶性组HF-BF#、HF-BF％和CEA水平均明显高于良性组,差异有统计学意义（P〈0.01）;相关性分析显示,胸腹水中HF-BF#和HF-BF％与CEA均未发现明显的关联性;经ROC曲线分析得到HF-BF#、HF-BF％、CEA的单独检测的ROC曲线下面积分别为0.820、0.737、0.933;而两项联合检测（HF-BF#＋CEA,HF-BF％＋CEA）的ROC曲线下面积均明显高于单独检测.结论：对于良恶性胸腹腔积液的鉴别,高荧光细胞和CEA的联合检测可以提供肿瘤细胞的筛选信息,具有较好的临床应用价值.

Objective： To investigate the value of combined detection of HF-BF%,HF-BF# and CEA in the differential diagnosis of benign and malignant hydrothorax or ascites. Methods： The hydrothorax or ascites of 110 patients admitted to the First People＇s Hospital of Zhaoqing from December to January 2014-2016 wascollected. The cancer patients （malignant group）in 53 cases, 57 cases of the non-cancer patients （benign group）. The CEA,highly fluorescent cells absolute value （HF-BF#）and percentage （HF-BP%）of ascites and pleura/effusions were detected, and related datawere conducted for statistical analysis. Results： The levels ofHF-BF#, HF-Blm/0 and CEA of the malignant group were significantly higher than those of the benign group （P〈0.01）. According to the Spearman correlation analysis, there is not obvious relevance between the HF-BF#, HF-BF % and CEA in hydrothorax or ascites. According to 1KOC curve analysis, the of single indicator detection ofHF-BF#, HF-Bt% and CEA area under the curve（AUC）was 0.820, 0.737 and 0.933, The AUC of the two combined detection indicators were significantly higher than those of single indicator detection. Conclusion： The combined detection of high- fluorescent cell and CEA can provide the presence of abnormal cells and has significant clinical attlication value.