磁共振弥散加权成像、表观扩散系数对乳腺癌化疗疗效的评价

Evaluation of DWI,ADC on the efficacy of chemotherapy for breast cancer

目的:探讨磁共振弥散加权成像(DWI)、表观扩散系数(ADC)对乳腺癌化疗疗效的评价。方法:选取我院2014年3月—2016年3月的45例化疗的乳腺癌进行MRI的疗效的诊断分析,化疗前进行MRI检查,化疗2~3月后再进行MRI检查,比较肿瘤大小,ADC值变化,增强扫描的横轴位及曲线的变化等。结果:化疗前的肿瘤大小(29.9±10.3)mm及体积大小(22 689.2±1 090.5)mm^3与化疗后的肿瘤大小(12.6±5.3)mm和体积大小(15 042.9±211.2)mm^3存在明显差异(P<0.05);化疗后患者的ADC_(mean)值(1 102.6±102.3)×10^(-6)mm^2/s和ADC_(min)值(1 042.9±211.2)×10^(-6)mm^2/s明显高于化疗前(849.9±120.3)mm^2和(715.2±100.5)mm^2/s,具有统计学意义(P<0.05);化疗前后时间-信号强度曲线(TIC)类型由Ⅲ型向Ⅰ型变化的趋势,且差异有统计学意义(P<0.05)。结论:乳腺癌化疗后进行MRI评价可以明显观察患者的病灶变化及ADC的变化,进行化疗后患者的曲线由Ⅲ型向Ⅰ型变化的趋势。

Objective： To study the efficacy of DWI and ADC in the treatment of breast cancer. Methods： From March 2014 to March 2016, we selected 45 cases of chemotherapy of breast cancer to analyze efficacy of MR1 diagnosis. All of the patients underwent MRI examination before chemotherapy and after chemotherapy for three months, compared before and after chemotherapy on tumor size, ADC value, enhanced scanning of the sagittal and time-intensity curve （TIC） changes. Results： The size of tumor was （29.9±10.3） mm and the volume of （22 689.2±1 090.5）mm3 before chemotherapy and tumor size was （12.6±5.3） mm and volume of （15042.9±211.2） mm3 after chemotherapy which had obvious difference（P〈0.05）. After chemothera- py in patients with ADCmean （1 102.6±102.3）×10^-6mm2/s and ADCmin（1 042.9±211.2）×10^-6mm2/s was significantly higher than that before chemotherapy （849.9±120.3） mm2 and （715.2±100.5） mm2/s, with statistical significance （P〈0.05）; before and after chemotherapy, the TIC type changed by the type m to I, and the difference was statistically significant（P〈0.05）. Conclusion： MRI evaluation after chemotherapy for breast cancer can reflect observe the changes of the lesions including ADC, and the trend of the change of TIC type m to I in patients after chemotherapy.