紫苏的化学成分研究

Study on chemical constituents from Perilla frutescens(L.) Britt

对紫苏的化学成分进行研究.采用75%乙醇提取紫苏,提取物通过大孔吸附树脂、硅胶柱色谱、ODS柱色谱进行分离,进一步应用半制备高效液相色谱进行纯化,应用核磁共振技术并参照相关文献对得到化学成分进行结构确定.共分离得到了5个化合物,分别为5-methoxyisolariciresinol、syringaresinol mono-β-D-glucoside、lyoniresinol、patrinalloside、patrinoside-aglucone.所有化合物均为首次从该植物中分离得到.

To study the chemical constituents of Perilla frutescens（L.） Britt. 75% Et OH extract of Perilla frutescens（L.） Britt. was separated by macroporous resin,normal phase chromatography,ODS and RP-HPLC to isolate natural compounds. And their structures were elucidated by NMR spectral analysis and the references. Five compounds were isolated from the plant,and all the compounds were identified as 5-methoxyisolariciresinol,syringaresinol mono-β-D-glucoside,lyoniresinol,patrinalloside,patrinoside-aglucone. All the compounds were isolated from the plant for the first time.