中性粒细胞-淋巴细胞比值及D-二聚体与急性脑梗死颈动脉狭窄的关系

The relationship between neutrophils to lymphocyte ratio and D-dimer and carotid artery stenosis degree in patients with acute cerebral infarction

目的观察颈动脉狭窄的急性脑梗死患者中性粒细胞-淋巴细胞比值(NLR)以及血清D-二聚体的变化,探讨其与颈动脉狭窄程度的关系。方法收集符合急性脑梗死诊断标准的住院患者130例,并行数字减影血管造影(DSA)明确血管病变,根据DSA结果将颈动脉狭窄急性脑梗死患者分为颈动脉轻度狭窄组(n=21)、中度狭窄组(n=83)、重度狭窄组(包括闭塞,n=26),同期选取造影结果正常患者(n=59)为对照组。分析NLR及D-二聚体与颈动脉狭窄程度的关系。结果颈动脉狭窄的脑梗死患者NLR及D-二聚体水平明显高于对照组,重度组平均NLR和血清D-二聚体与中、轻度狭窄组比较差异有统计学意义(P<0.05)。结论 NLR和D-二聚体水平呈正相关,可评估颈动脉狭窄的严重程度。

Objective To observe the changes of neutrophils to lymphocyte ratio （NLR） and D-dimer in patients with carot- id artery stenosis and acute cerebral infarction （ACI）, and to analyze the relationships among NLR, D-dimer and carotid artery ste- nosis degree. Methods Patients （n=130） with ACI who were eligible diagnostic criteria of ACI were studied,and were divided in- to three groups： mild group （n =21）, moderate group （n =83） and severe group （n =26, including 1 case of occlusion）, on the ba- sis of cerebrovascular angiography. Patients （n = 59） with normal cerebrovaseular angiography were selected as a control. Then the relationship between NLR and Ddimer and carotid artery stenosis degree were analyzed. Results The levels of mean NRL and D-dimer were higher in ACI patients than normal group. The mean NRL and D-dimer levels were significantly differences among the mild, moderate and severe groups. Conclusion NLR and D-dimer are positively correlated with the degree of carotid artery stenosis,and have a prompt significance with carotid artery stenosis degree.