黄芪丹参汤治疗脑梗死恢复期的临床疗效及炎性因子水平的影响

Clinical Effect of Huangqi Danshen Decoction in the Treatment of Cerebral Infarction during Convalescence and Its Influence on the Level of Inflammatory Factors

目的探究黄芪丹参汤治疗脑梗死的临床疗效及对炎性因子水平的影响。方法选取脑梗死恢复期患者70例随机分为2组,各35例。对照组予以依达拉奉30 mg静脉注射,每天1次,阿司匹林1.0 g,每天1次;试验组在对照组的基础上予以黄芪丹参汤,日1剂。2组均予以连续治疗14 d,治疗结束后比较2组临床疗效,血清炎性因子以及不良反应发生率。结果治疗后与对照组相比,试验组临床总有效率较高,血清MMP-9以及hs-CRP水平较低(P<0.05),不良反应发生率无明显差异(P>0.05)。结论黄芪丹参汤对脑梗死恢复期的患者疗效较好,可能与下调血清MMP-9、hs-CRP炎性因子水平有关。

Objective To explore the clinical effect of Huangqi Danshen decoction in the treatment of cerebral infarction during convalescence and its influence on the level of inflammatory factors. Methods 70 patients with cerebral infarction in our hospital were randomly divided into two groups, with 35 cases in each group. The control group received edaravone 30 mg iv, qd, aspirin 1.0,qd, and the experiment group received Huangqi Danshen secoction, qd on the basis of the control group. Two groups were treated for14 days, and the clinical effects, serum inflammatory factors and adverse reactions were compared. Results Comparing with the control group, the total clinical effective in the experiment group was higher, levels of MMP-9 and hs-CRP in the experiment group were lower（P〈0.05）, and there was no significant difference in the incidence of adverse reactions（P〈0.05）. Conclusion Huangqi Danshen decoction is effective in the treatment of cerebral infarction at recovery stage, which may be related to down-regulation of serum MMP-9 and hs-CRP levels.