NLRs炎症体在肺感染性疾病中的作用机制研究

Study on the Activation Mechanism of NLRs Inflammasome in Bacterial Lung Infection

固有免疫系统是机体防御病原菌入侵的第一道防线,在肺感染性疾病中起重要作用。NLRs(nucleotide-binding oligomerization domain-like receptors)是细胞内固有免疫系统中识别病原菌的一类重要受体,由NLRs形成的炎症体参与多种肺感染性疾病的发生与发展,诱导促炎性细胞因子的生成、或细胞凋亡。讨论了主要的NLRs炎症体的组成、活化机制及在肺感染性疾病中的作用。

Innate immune system is the first line of host defense against pathogens, and plays an important role in the disease of pulmonary infection. NLRs（nucleotide-binding oligomerization domain-like receptors） represent a group of key sensoes for pathogen, and NLRs inflammasomes have close relationship with pulmonary diseases. Here the composition, activation mechanism and the role of NLRs inflammasomes in bacterial lung infection were reviewed.