美沙拉嗪与康复新液联合治疗溃疡性结肠炎的有效性评定

Evaluation on the Effectiveness of Ulcerative Colitis Treated with Mesalazine plus Kangfuxin Liquid

为探讨美沙拉嗪口服与康复新液保留灌肠联合治疗溃疡性结肠炎的有效性,将80例溃疡性结肠炎患者随机分为对照组和治疗组,每组40例。对照组采用单纯口服美沙拉嗪治疗,治疗组采用口服美沙拉嗪与康复新液保留灌肠联合治疗。比较2组疾病干预前后患者促炎性细胞因子水平;血性腹泻、里急后重、呕吐、腹痛消失时间及用药治疗的安全性。结果显示,治疗组总有效率为97.5%,对照组总有效率为75.0%,治疗组高于对照组(P<0.05);干预前2组促炎性细胞因子水平相近(P>0.05),干预后治疗组促炎性细胞因子水平低于对照组(P<0.05);治疗组血性腹泻、里急后重、呕吐、腹痛消失时间短于对照组(P<0.05)。2组患者无明显不良反应。结果表明,美沙拉嗪与康复新液联合治疗溃疡性结肠炎有效性高,可缩短疗程,加速症状消失,降低促炎性细胞因子水平,改善机体微炎症状态,安全有效,值得推广。

This study was to explore the effectiveness of ulcerative colitis（UC） treated with Mesalazine plus Kangfuxin Liquid, randomly divided 80 cases of UC into control group and treatment one,40 cases for each, which the former received alone oral Mesalazine, the latter adopted the combination of oral Mesalazine and Kangfuxin liquid for retention enema; then compared following indexes as the patient＇s level of proin- flammatory cytokine before and after intervention, the disappeared time of bloody diarrhea, tenesmus, vomiting and abdominal pain,as well as the safety of medication,etc between the two groups.As results,the to- tal effective rate of the latter was significantly higher than that of the former（97.5% vs 75.0%, P 〈0.05） ; before intervention in the patient＇s proinflammatory cytokine level there was no statistical difference be- tween the two groups（ P 〉0.05）,but after intervention in the patient＇s level of proinflammatory cytokine, in the disappeared time of bloody diarrhea,tenesmus,vomiting and abdominal pain, the latter was signifi- cantly lower,shorter than the former（ P 〈0.05 ,all） ;in both groups no evident adverse reaction was found. Results show that the effectiveness of UC treated with Mesalazine plus Kangfuxin liquid is high. It can shorten treatment course, accelerate symptoms disappearing, decrease the proinflammatory cytokine level, and improve body＇s mini-inflammatory situation, which is safe and effect, worthy to be popularized to used.