3-羧4-甲-5-丙基呋喃戊酮酸与糖尿病

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid and diabetes mellitus

3-羧4-甲-5-丙基呋喃戊酮酸（CMPF）是一种内源性的呋喃脂肪酸代谢产物，代谢组学研究发现，妊娠期糖尿病、糖耐量减低以及2型糖尿病患者，血清CMPF水平明显升高。血清高浓度的CMPF造成糖耐量减低，抑制葡萄糖刺激的胰岛素分泌，并且降低葡萄糖的利用率。研究发现，CMPF可以导致线粒体功能异常，减少葡萄糖诱导的三磷酸腺苷积累，诱导氧化应激反应，造成转录因子的调节异常，并且增加了晚期糖基化终末产物及胰岛素前体的合成，最终导致胰岛素生物合成减少。因此，进一步探索CMPF与糖代谢的关联，可为探索糖尿病的发生及发展提供新的方向。

3-earboxy-4-methyl-5-propyl-2-furanpropanoic acid （CMPF） is an endogenous metabo- lites of furan fatty acids. Metabolomics research found that patients with gestational diabetes, impaired glu- cose tolerance or type 2 diabetes mellitus had significantly higher serum CMPF levels. Elevated serum con- centration of CMPF causes impaired glucose tolerance, inhibites glucose stimulated insulin secretion and de- creases glucose utilization. Further research found that CMPF can lead to mitochondrial dysfunction, reduce glucose-induced accumulation of adenosine triphosphate, induce oxidative stress response, resulting in dys- regulation of transcription factors and increasing formation of advanced glycation end-product and immature proinsulin, finally leading to reduced insulin biosynthesis. Therefore, further exploration of the relationship between CMPF and glycolipid metabolism can give new direction for studies of the occurrence and develop- ment of diabetes.