1，5-脱水葡萄糖醇与糖尿病及其并发症

1,5-Anhydroglucitol in diabetes and its complications

1，5-脱水葡萄糖醇（1，5-AG）结构上类似葡萄糖，具有封闭吡喃环结构，稳定且不参与体内代谢，因尿糖竞争性抑制其重吸收而降低。1，5-AG反映短期血糖控制水平，可筛查出平均血糖控制尚可但伴有餐后高血糖（PPH）或血糖波动者，对HbA1c监测血糖作合理补充，并辅助鉴别糖尿病亚型及预测糖尿病血管并发症，有较好的临床价值。

1,5-anhydroglucitol （ 1,5-AG） is structurally similar to glucose, with a closed pyran ring structure that confers metabolic stability and does not participate in vivo metabolism, which reduces the tubu- lar reabsorption by competitive inhibition of urine glucose. 1,5-AG reflects short-tel^n glycemie status, de- tects moderately or well-controlled diabetes which is accompanied with postprandial hyperglycemia （ PPH ） and glucose fluctuation, and makes a reasonable supplement for HbAle in glucose monitoring, assists identi- fy the subtypes of diabetes and predicts diabetic vascular complications, thus has a dramatical clinical significance.