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1,5-脱水葡萄糖醇与糖尿病及其并发症 被引量:3

1,5-Anhydroglucitol in diabetes and its complications
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摘要 1,5-脱水葡萄糖醇(1,5-AG)结构上类似葡萄糖,具有封闭吡喃环结构,稳定且不参与体内代谢,因尿糖竞争性抑制其重吸收而降低。1,5-AG反映短期血糖控制水平,可筛查出平均血糖控制尚可但伴有餐后高血糖(PPH)或血糖波动者,对HbA1c监测血糖作合理补充,并辅助鉴别糖尿病亚型及预测糖尿病血管并发症,有较好的临床价值。 1,5-anhydroglucitol ( 1,5-AG) is structurally similar to glucose, with a closed pyran ring structure that confers metabolic stability and does not participate in vivo metabolism, which reduces the tubu- lar reabsorption by competitive inhibition of urine glucose. 1,5-AG reflects short-tel^n glycemie status, de- tects moderately or well-controlled diabetes which is accompanied with postprandial hyperglycemia ( PPH ) and glucose fluctuation, and makes a reasonable supplement for HbAle in glucose monitoring, assists identi- fy the subtypes of diabetes and predicts diabetic vascular complications, thus has a dramatical clinical significance.
作者 刘敏 王彦 Liu Min, Wang Yan.(Department of Endocrinology, The First Hospital, Shanxi Medical University, Taiyuan 030000, Chin)
出处 《国际内分泌代谢杂志》 2018年第2期106-109,共4页 International Journal of Endocrinology and Metabolism
关键词 1 5-脱水葡萄糖醇 糖尿病 餐后高血糖 糖尿病并发症 1,5-Anhydroglucitol Diabetes mellitus Postprandial hyperglycemia Diabetic complications
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